UNIVERSITAS AIRLANGGA



Detail Article

Journal Of Emergency

ISSN 2301-7864

Vol. 3 / No. 1 / Published : 2014-06

Order : 5, and page :28 - 35

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Original Article :

Intraperitoneal adhesion prevention with an intramuscular injection of diphenhydramine perioperative

Author :

  1. IGB Adria Hariastawa*1
  2. Dono Marsetio W*2
  1. Dosen Fakultas Kedokteran
  2. Mahasiswa Fakultas Kedokteran

Abstract :

Background : intraperitoneal adhesions are the most coomon cause of intestinal obstruction. Incidence of intraperitoneal adhesions after laparotomy is still quite high and still an usolved problem. Approximately 55% of patients after laparotomy occures adhesio, with approximately 25% of patients experienced obstruction. Many attempted and tested ways to reduce or prevent the occurence of intraperitoneal adhesions, one ith the administration of anti-hitstamine drugs (Diphenhydramine).   Objective :  to determine the effect of perioperative intramuscular injection of  Dipenhydramine against the occurence of intraperitoneal adhesions after laparotomy in rabbits.   Methods : this research is an experimental study with a Randomized post test only control group design with rabbits as an animal subject (Oryctalagus cuniculus) that fit the inclusion criteria and requirements of healthy rabbits. Laarotomy and peritoneal manipulation performed on 22 rabbits as experimental animals which were divided into two groups with each sample number 11. The treament group was performed a perioperaive administration of intramuscular injection of diphenhydramie 30 minutes prior to the manipulation of the peritonesum and for 3 consecutive days, while the control group was not given an intramuscular injection of dipenhydramine perioperative administration. The second laparotomy will be performed 10 days after the first surgery and adhesion assesment was done by using adhesion scoring system of Fiedler which was a modification score of Boyers in 1996.   Result : there has been found statistically significant difference with P<0.0001 for the assesment of score of extent area, score of severity, score of tenacity and P=0,002 for the assement of score of inflamation.   Conclusion :Intramuscular perioperative injection of diphenhydramine can prevent the occurence of intraperitoneal adhesions after laparotomy in rabbits based on the assement of adhesion scoring system. 

Keyword :

intra peritoneal adhesions, intestinal obstruction, prevention, diphenhydramine, injection,


References :

Devens K,(1963) Recurrent Intestinal Obstruction in The Neonatal Period 38:118 : Arch. Dis. Child





Archive Article

Cover Media Content

Volume : 3 / No. : 1 / Pub. : 2014-06
  1. Role Of Keratinocyte Progenitor Adipose Derived Stem Cells In The Epithelialization Of Skin Wound Healing In Rabbits
  2. Effect Of Oral Pomegranate (punica Granatum) Peel Aqueous Extract On Macrophage, Fibroblast And Collagen Thickness In Burn Wound Healing
  3. The Effect Of Amnion Freeze-drying To Prevent Adhesion In Rabbit Tendon Achilles Healing
  4. The Comparation Of The Use Of Multifilament Polyglycolide And Polyglyconate (barbed Suture) In Small Intestine Anatomosis With The One Layer Continous Technique
  5. Intraperitoneal Adhesion Prevention With An Intramuscular Injection Of Diphenhydramine Perioperative
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  7. Clinical And Laboratory Profiles Relationships Of Preeclampsia-eclampsia Patients With Maternal Mortality In The Dr. Soetomo Hospital Surabaya
  8. The Difference Of Internal Diameter Of The Ring On Reponible Lateral Inuinal Hernia With Incarserated Lateral Inguinal Hernia On Children

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