UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 1 / Published : 2015-01

Order : 3, and page :13 - 15

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Original Article :

Bactericidal effect of topical vitis vinifera to methicillin-resistant staphylococcus aureus (mrsa) on rattus norvegicus skin wound

Author :

  1. Beatrix Curie*1
  2. Lobredia Zarasade*2
  3. M Sjaifuddin Noer*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Methicillin Resistant Staphylococcus aureus (MRSA) is one of the most common pathogens worldwide that can cause variety of skinand soft tissue infection and can be fatal causing septicemia. Searching for drug and chemical compounds against MRSA is still indemand. Grape (Vitis Vinifera) is consumed widely around the world, and the seed is considered as a waste product but study invitro proven to be a rich source of polyphenolic compounds that show antibacterial effect against MRSA. The aim of this study is toinvestigate the antibacterial effect of grape seed extract on MRSA on white rat (Rattus norvegicus) Wistar strain skin wound andcompare the antibacterial effect to mupirocin’s effect on MRSA. Experimental research design using posttest only controls groupdesign. The wound at the back site of 27 healthy male white rats Wistar strain (Rattus norvegicus) inoculated with MRSA. The swabspecimens taken 6 hours after inoculation of MRSA, on day 1 and day 3 after the treatment with grape seed extract (Vitis vinifera)and mupirocin for microbiological examination to count the number of colonies. On all of the wounds in which were applied topicalgrape seed extract, the number of colonies of MRSA was significantly raised with respect to the control in 1 x 24 hours (p < 0,005)and decreased (p < 0,0001) after 3 x 24 hours, while treated with mupirocin significantly decreased within 1 x 24 hours. Grape seedextract has antibacterial effect, but it has slower effect compared to mupirocin.(FMI 2015;51:13-15)

Keyword :

MRSA, antibacterial effect, Vitis vinifera, polyphenolic,


References :

Alex A and Letizia M ,(2007) Community-acquired methicillin-resistant Staphylococcus aureus: considerations for school nurses 23, 210-213 : J Sch Nurs

Al-Habib A, Al-Saleh E, Safer AM, Afzal M ,(2010) Bactericidal effect of grape seed extract on methicillin-resistant Staphylococcus aureus (MRSA) 35, 357-364 : J Toxicol Sci





Archive Article

Cover Media Content

Volume : 51 / No. : 1 / Pub. : 2015-01
  1. Bacterial And Antibiotics Sensitivity Pattern In Neonatal Sepsis Patients
  2. The Metformin And Hyperbaric Oxygen Therapy On The Nuclear Factor Kappa β (nf-κβ) And Fibroblast Growth Factor (fgf) Expression In The Wound Of Hyperglycemic Rats
  3. Bactericidal Effect Of Topical Vitis Vinifera To Methicillin-resistant Staphylococcus Aureus (mrsa) On Rattus Norvegicus Skin Wound
  4. Cardiac Stress Marker Nt-probnp As An Indicator Of Changes In Cardiac Function Post Percutaneous Coronary Intervention
  5. Correlation Between Plasma Nitric Oxide Level And Coronary Artery Stenosis Severity Based On Sullivan Scoring System In Stable Angina Patients
  6. Correlation Between Exclusive Breastfeeding And The Incidence Of Allergy Amongst Children Age ≥ 5 Years Old In The Department Of Paediatric, Dr. Soetomo Hospital, Surabaya
  7. Gastrointestinal Tolerability Of Diclofenac Sodium And Meloxicam In Osteoarthritis Patient
  8. Megadose Methylprednisolone On Total Lymphocyte Count And Disease Activity In Systemic Lupus Erythematosus (sla)
  9. Dexamethasone Study For Prenatal Lung Maturation On Lecithin/sphingomyelin Ratio In Women At Risk Of Preterm Birth
  10. The Use Of Fetal Free Dna As Non-invasive Techniques On Sex Identification
  11. Case Report: Percutaneus And Surgical Transluminal Angioplasty As Complementary Therapies For Leukemic Patients With Acute Limb Ischemic Manifestations
  12. The Correlation Between The Exclusive Breastfeeding For Six Months, Mother's Education Level, Occupation And Kpsp Scores In Children Age 6 To 24 Months
  13. Caffeine May Be Safe Forwhite Male Rats Bone Density

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