UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 1 / Published : 2015-01

Order : 13, and page :74 - 79

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Original Article :

Caffeine may be safe forwhite male rats bone density

Author :

  1. Ivan Satria Pratama*1
  2. Achmad Basori*2
  3. Lukas Widhiyanto*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

High consumption of caffeine, believed by some scientist, can cause osteoporosis which marked by decrease in bone mineral densityand destruction of bone micro architecture. The purpose of this experiment, was to prove whether caffeine could decrease bonemineral density which lead into osteoporosis or not. The experiment used pretest-posttest design as its method, and the sample forthis experiment were 40 White Male Rats (Rattus norvegicus) which were separated into 4 groups each contain 10 rats. One groupused as control group, given 3 ml of water for each rat. While the other groups received 3 different dose, there were 2.25 mg, 6.75mg, 11.25 mg and given daily for a month. Bone density was measured with DBM Sonic 1200. Data analysis was done usingAnalysis of Variance (Anova) test. The level of significance in this experiment was 0.089. The results meant that there were nodifferent of bone mineral density between control group and groups that had been given with caffeine. Theoretically caffeine canreduce bone density but statistically there were no effect of caffeine in decreasing bone mineral density. (FMI 2015;51:74-79)

Keyword :

osteoporosis, bone mineral density, caffeine,


References :

Nawrot P, Jordan S, Eastwood J, Rotstein J, Hugenholtz A, Feeley M ,(2003) Effects of caffeine on human health 20, 1-30 : Food Addit Contam

Tsuang YH, Sun JS, Chen LT, Sun SCK, Chen SC ,(2006) Direct effects of caffeine on osteoblastic cells metabolism: the possible causal effect of caffeine on the formation of osteoporosis 1, 7 : J Orthop Surg





Archive Article

Cover Media Content

Volume : 51 / No. : 1 / Pub. : 2015-01
  1. Bacterial And Antibiotics Sensitivity Pattern In Neonatal Sepsis Patients
  2. The Metformin And Hyperbaric Oxygen Therapy On The Nuclear Factor Kappa β (nf-κβ) And Fibroblast Growth Factor (fgf) Expression In The Wound Of Hyperglycemic Rats
  3. Bactericidal Effect Of Topical Vitis Vinifera To Methicillin-resistant Staphylococcus Aureus (mrsa) On Rattus Norvegicus Skin Wound
  4. Cardiac Stress Marker Nt-probnp As An Indicator Of Changes In Cardiac Function Post Percutaneous Coronary Intervention
  5. Correlation Between Plasma Nitric Oxide Level And Coronary Artery Stenosis Severity Based On Sullivan Scoring System In Stable Angina Patients
  6. Correlation Between Exclusive Breastfeeding And The Incidence Of Allergy Amongst Children Age ≥ 5 Years Old In The Department Of Paediatric, Dr. Soetomo Hospital, Surabaya
  7. Gastrointestinal Tolerability Of Diclofenac Sodium And Meloxicam In Osteoarthritis Patient
  8. Megadose Methylprednisolone On Total Lymphocyte Count And Disease Activity In Systemic Lupus Erythematosus (sla)
  9. Dexamethasone Study For Prenatal Lung Maturation On Lecithin/sphingomyelin Ratio In Women At Risk Of Preterm Birth
  10. The Use Of Fetal Free Dna As Non-invasive Techniques On Sex Identification
  11. Case Report: Percutaneus And Surgical Transluminal Angioplasty As Complementary Therapies For Leukemic Patients With Acute Limb Ischemic Manifestations
  12. The Correlation Between The Exclusive Breastfeeding For Six Months, Mother's Education Level, Occupation And Kpsp Scores In Children Age 6 To 24 Months
  13. Caffeine May Be Safe Forwhite Male Rats Bone Density

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