UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 4 / Published : 2012-10

Order : 7, and page :180 - 185

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Original Article :

Clinical profile of children with steroid-sensitive idiopathic nephrotic syndrome relapsing in the first year at dr. soetomo hospital, surabaya

Author :

  1. Wilbert Sudihardjo*1
  2. Risky Vitria Prasetyo*2
  3. Sri Umijati*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Nephrotic Syndrome (NS) is characterized by massive proteinuria, hypoalbuminemia, accompanied by oedema, and hypercholesterolemia. It can be classified into steroid sensitive and resistant NS. Relapses were common in steroid sensitive NS during the first year after they got diagnosed. The aim of this study is to know the distribution of NS patients who get relapsed based on gender, age, number of relapses, blood pressure, hematuria, glomerular filtration rate (GFR), albumin, and cholesterol. This was an observational descriptive study was performed with a total sampling to obtain the sample. Sample is children aged 1-18 years with nephrotic syndrome who got relapse during the first year after they were diagnosed in Dr. Soetomo Hospital Surabaya January 2001 – December 2011. There are relapses found in 35 patients in which 29 patients (82,8%) are male and 6 patients (17,2%) are women. There are 27 non-frequent relapsers (77,1%) and 8 frequent relapsers (22,9%). There were 27 patients (77,1%) aged 1-6 years, 7 patients (20%) aged 7-12 years, and 1 patient (2,9%) aged 13-18 years. Well-nourished is found in 26 patients (74,2%), under-nourished are is found in 4 patients, severe malnourished is found in 4 patients (11,5%), overweight is found in 0 patient (0%), and obesity found in 1 patient (2,8%). There are 18 patients (51,5%) with hypertension and 17 patients (48,5%) are normal. Hematuria is only found in 5 patient (14,3%) when the other 30 patients (85,7%) are not. Low albumin serum found in 29 patients (82,9%) and 6 patients (17,1%) were normal. Low GFR was found in 8 patients (22,9%) and 27 patients (77,1%) in normal value. Cholesterol serum is elevated in 32 patients (91,5%) when the 3 others are normal (8,5%). In conclusion, there are more non-frequent relapsers than frequent relapsers and also more men than women. Relapses commonly found in patients aged 1-6 years. Most of them are well nourished. Some of them are having hypertension and hematuria. Low GFR level was found in a few patients. Decreased in albumin serum and elevation of cholesterol serum are common in relapsing patients. (FMI 2012;48:180-185)

Keyword :

Clinical profile, steroid sensitive nephrotic syndrome, relapse, first year,


References :

Branten AJ, Vervoort G, Wetzels JF,(2005) Serum creatinine is a poor marker of GFR in nephrotic syndrome - : Nephrol Dial Transplant

Ferrari P,(2003) Cortisol and the renal handling of electrolytes: role in glucocorticoid-induced hypertension and bone disease - : Best Pract Res Clin Endocrinol Metab





Archive Article

Cover Media Content

Volume : 48 / No. : 4 / Pub. : 2012-10
  1. Antibacterial Activity Of Belimbing Wuluh (averrhoa Bilimbi Linn) Extract On Salmonella Typhi Growth
  2. Oral And Topical Aloe Vera Extract Administration In Diabetic Mice (mus Musculus) Wound Healing Process
  3. Effect Of Combined 500 Mg Vitamin C And 200 Iu Vitamin E On Plasma Malondialdehyde Level After Physical Exercise In Diving Athletes
  4. Antibacterial Activity Of Kunyit (curcuma Longa) Leaves Extract On Staphylococcus Aureus Examined Using Dilution Method
  5. Antibacterial Effect Of Strawberry (fragaria X Ananassa) Extract On Pathogenic Serotype 1-11 Escherichia Coli Revealed Using Dilution Method
  6. Guava (psidium Guajava L.) Juice Is Effective In Lowering Blood Glucose Level In Mice (mus Musculus)
  7. Clinical Profile Of Children With Steroid-sensitive Idiopathic Nephrotic Syndrome Relapsing In The First Year At Dr. Soetomo Hospital, Surabaya
  8. The Effects Of Soot Particulate Exposure On Tnf-α Expression In The Mechanism Of Cardiovascular Disorders
  9. Atomoxetine Therapy Effectiveness In Children With Adhd At Day Care, Dr. Soetomo Hospital, Surabaya
  10. Sweet Star Fruit Reduces Blood Pressure In Normotensive Subjects

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