UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 1 / Published : 2008-01

Order : 8, and page :35 - 40

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Original Article :

Contralateral renal fibroblast and tubular cell apoptosis and proliferation in artificial unilateral total urethral obstruction in rabbits

Author :

  1. Prijambodo Tjaturadi *1
  2. Soetojo*2
  1. Department of Urology Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya
  2. Department of Urology Airlangga University School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

We defined total unilateral obstruction influence on apoptosis and proliferation of renal tubular cells and fibroblasts in contralateral kidney in rabbits. This study used post control group design of 40 rabbits that were divided randomly into 4 groups. Group I received total unilateral ligation of ureter for 7 days and nefrectomy of contralateral kidneys and we found apoptosis (with ‘apopTag’) in renal tubular cells. Using HE staining, we found proliferation of tubular cells and fibroblasts. Group II was treated similarly for 14 days. Group III & IV were controls for 7 and 14 days. The results showed that apoptosis proportion of tubular cells in contralateral kidneys was not significantly different from those in control groups for 7 days (p > 0.05), but significantly different from those treated for 14 days (p < 0.05). The proportion of apoptosis of tubular cells in contralateral kidneys was not significantly different between that in 7 days and 14 days (p > 0.05). The proliferation of tubular cells and fibroblasts in contralateral kidneys was significantly different than that in control groups for 7 and 14 days (p < 0.05), and also different in contralateral kidneys in 7 days as compared to that in 14 days (p < 0.05). In conclusion, apoptosis of tubular cells in contralateal kidneys is significantly different than that in controls of 14 days treatment. The proliferation of tubular cells and fibroblasts in contralateral obstruction is significantly different in 7 and 14 days than controls.

Keyword :

apoptosis, proliferation, contralateral, urethral obstruction,


References :

Gillenwater, JY,(1992) The pathophysiology of urinary tract obstruction, in Campbell\’s Urology, 6th edn Philadelpia : WB Saunders Company

Klahr, S & Morrissey, J,(2002) Obstructive nephropathy and renal fibrosis - : Am J Physiol Renal Physiol





Archive Article

Cover Media Content

Volume : 44 / No. : 1 / Pub. : 2008-01
  1. Correlation Between Dengue Virus Serotype And Humoral Immune Response In Pediatric Dengue Hemorrhagic Fever
  2. Modulation Of Immunoglobulin G (igg) And Cortisol Responses In Breathing Exercise
  3. Prediction Of Distribution Pattern Of Aedes Aegypti As Dhf Main Vector In Jember
  4. Difference Of Interferon Gammalevel (release Assay) In Nurses Exposed To Mycobacterium Tuberculosis And Active Tuberculous Patients
  5. Molecular Expression Of Estrogen Receptor Alpha (erα) And Interleukin 6 (il-6) On Acceleration Of Healing Process Of Long Bone Shaft Fracture By Immediate Repetitive Axial Compression Tension Stabilization (ireact)
  6. Il-4 In Peripheral Blood Mononuclear Cells And Bronchoalveolar Lavage Patients With Pulmonary Tuberculosis Before And After Treatment With Oral Anti-tuberculosis Drugs
  7. Effect Of Oral Curcumin And Immobilization On The Diameter Of Skeletal Muscle Fiber In Rattus Norvegicus
  8. Contralateral Renal Fibroblast And Tubular Cell Apoptosis And Proliferation In Artificial Unilateral Total Urethral Obstruction In Rabbits
  9. Polymorphism C3435t Of The Mdr-1 Gene Predicts Response To Preoperative Chemotherapy In Locally Advanced Breast Cancer With Her2/neu Expression
  10. Review Article:challenge Of Environmental Toxicology In Reformation Era
  11. Bone Morphogenetic Protein 4 (bmp4) And Prostaglandin Alpha (pge2α) Molecular Expression In Healing Process Acceleration Of Long Bone Shaft Fracture Using Immediate Repetitive Axial Compression Tension Stabilization (ireact)
  12. Treatment Response Of Chronic Myelogenic Leukemia In Dr. Soetomo Hospital
  13. Review Article And Clinical Experience:the Obesity Pandemic: The “time-bomb Disease” In The Future?where Have We Been? And What Should We Do?

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