UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 51 / No. 1 / Published : 2015-01

Order : 5, and page :22 - 30

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Original Article :

Correlation between plasma nitric oxide level and coronary artery stenosis severity based on sullivan scoring system in stable angina patients

Author :

  1. Farhanah Meutia*1
  2. J Nugroho Eko Putranto*2
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Nitric oxide (NO) is a major antiatherosclerotic factor produced by the endothelium. Endothelial dysfunction that causes impairedbioavailability of NO, is an early marker of atherosclerosis. Various angiographic scoring system are used to quantify thecharacteristics of atherosclerotic coronary artery lesions. Sullivan scoring system is one of the angiographic scoring system that candemonstrate a link between the severity of coronary artery lesions with atherosclerotic plaque burden. The main objective of thisstudy to prove the correlation between plasma NO level and severity of coronary artery stenosis based on Sullivan scoring system instable angina patient. This was an observational analytic study, cross sectional, involving 25 patients with stable angina whounderwent catheterization. Plasma NO levels significantly correlated well with the severity of coronary artery stenosis based onSullivan vessel score (r = -0,75, p = 0,000), with the severity of coronary artery stenosis based on Sullivan stenosis score (r = -0,67;p = 0,000), and with the severity of coronary artery stenosis based on Sullivan extent score (r = -0,63; p = 0,001). The higherplasma NO level, the lower the degree of severity of coronary artery stenosis by Sullivan vessel score, stenosis score dan extentscore. In conclusion, plasma NO levels has a significant correlation with the severity of coronary artery stenosis based on Sullivanscoring system in patients with stable angina. (FMI 2015;51:22-30)

Keyword :

nitric oxide, Sullivan scoring system, stable angina,


References :

Bigi R, Cortigiani L, Colombo P, Desideri A, Bax JJ, Parodi O ,(2003) Prognostic and clinical correlates of angiographically diffuse non-obstructive coronary lesions 89, 1009-1013 : Heart

Cassar A, Holmes DR Jr, Rihal CS, Gersh BJ ,(2009) Chronic coronary artery disease: diagnosis and management 84, 1130-1146 : Mayo Clin Proc





Archive Article

Cover Media Content

Volume : 51 / No. : 1 / Pub. : 2015-01
  1. Bacterial And Antibiotics Sensitivity Pattern In Neonatal Sepsis Patients
  2. The Metformin And Hyperbaric Oxygen Therapy On The Nuclear Factor Kappa β (nf-κβ) And Fibroblast Growth Factor (fgf) Expression In The Wound Of Hyperglycemic Rats
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  4. Cardiac Stress Marker Nt-probnp As An Indicator Of Changes In Cardiac Function Post Percutaneous Coronary Intervention
  5. Correlation Between Plasma Nitric Oxide Level And Coronary Artery Stenosis Severity Based On Sullivan Scoring System In Stable Angina Patients
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