UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 2 / Published : 2010-04

Order : 4, and page :102 - 111

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Original Article :

Differences of tumor necrosis factor alpha (tnf-α) plasma concentration in malaria patients with anemia and without anemia

Author :

  1. Ety Retno Setyowati*1
  2. Endang Retnowati*2
  3. Juli Soemarsono*3
  1. Department of Clinical Pathology, Faculty of Medicine, Airlangga University
  2. Department of Clinical Pathology, Faculty of Medicine, Airlangga University
  3. Department of Clinical Pathology, Faculty of Medicine, Airlangga University

Abstract :

Anemia is an important complication of malaria. The pathogenesis of malaria anemia is not well understood. Some inflammatory cytokines such as TNF-α was believed to be involved in the pathogenesis of malaria anemia because concentration of plasma TNF-α was increased in malaria patients with anemia. The aim of this study was to compare the concentration of plasma TNF-α in malaria patients with anemia and without anemia. Concentration of plasma TNF-α in 20 malaria patients with anemia and 20 plasma samples malaria patients without anemia from patients at Tanjung and Gangga primary health centers, west Lombok during December 2007 until June 2008 was measured using ELISA. The results were analyzed using 2 sample t test. The average concentration of plasma TNF-α in  falciparum malaria patients with anemia 145.27 ± 24.18 pg/ml while the average concentration of plasma TNF-α in falciparum malaria patients without anemia 36.26 ± 16.18 pg/ml. The average concentration of plasma TNF-α in vivax malaria patients with anemia  97.83 ± 13.96 pg/ml while the average concentration of plasma TNF-α in vivax malaria patients without anemia 30.41 ± 14.57 pg/ml. We conclude that TNF-α concentration in malaria patients with anemia is significantly higher than the TNF-α concentration in malaria patients without anemia (p = 0.000...).

Keyword :

Falciparum malaria, vivax malaria, Anemia, TNF-α , ELISA,


References :

Abrams, ET, Kwiek, JJ, Mwapasa, V, Kamwendo, DD, Tadesse, E, Lema, VM, Molyneux, ME, Rogerson, S,(2005) Malaria During Pregnancy and Foetal Haematological Status in Blantyre - : Malaria Journal

Baptista, JL, Vanham, G, Wery, M, Van, & Marck, E,(1997) Cytokine Levels During Mild and Cerebral falciparum Malaria in Children Living in a Mesoendemic Area - : Trop Med Int Hlth

Beutler, B, & Cerami, A,(1990) TNF and Lymphotoxin as Primary Mediators of Tissue Catabolism, Inflammation and Shock, in Lymphokines and The Immune Response, 2nd ed. Florida : CRC Press





Archive Article

Cover Media Content

Volume : 46 / No. : 2 / Pub. : 2010-04
  1. Polymorphism Of Natural-resistance-associated Macrophage Protein 1 (nramp1) D543n Gene And Expression Of Nramp1 On Lung Tuberculosis Patients And Nurses In Surabaya
  2. 45 Kda Fimbria Protein Of Proteus Mirabilis As Hemagglutinin And Adhesion Protein
  3. Diagnostic Value Of Widal Slide Assay Using One Phage Type Local Antigen Compared With Four Phage Types Local Antigen In Typhoid Fever Patients In Surabaya
  4. Differences Of Tumor Necrosis Factor Alpha (tnf-α) Plasma Concentration In Malaria Patients With Anemia And Without Anemia
  5. Differences Of Epidermal Growth Factor (egf) Concentration Between Unpreserved And Preserved Amniotic Membrane
  6. Cytotoxicity Effect Of Curcuma Aeruginosa Extract On Fibroblast With Mtt Assay Method
  7. Correlation Between Blood Serotonin Level With Consciousness Level And Depression Symptoms In Moderate Brain Injury Patients
  8. Blood Serotonin Level With Depression Situation And Neurocognitive As A Reflection Of Neuron Condition In Six Months After Moderate Brain Injury
  9. Association Between Heart Disease In Pregnancy With Cardiac Events
  10. Endoscopic Finding Of Upper Gastrointesinal Bleeding At Dr Soetomo Hospital, Surabaya
  11. Correlation Between Tnf-α, Il-1β, Pge2 And Spla2 Levels With Severity Of Dengue Hemorrhagic Fever
  12. Case Report: Auditory Neuropathy In Dr. Soetomo Hospital

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