UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 43 / No. 3 / Published : 2007-07

Order : 2, and page :136 - 140

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Original Article :

Effect of curcumin on the levels of total cholesterol, ldlcholesterol, the amount of f2-isoprostan and foam cell in aortic wall of rats with atherogenic diet

Author :

  1. Ika Fikriah*1
  1. Department of Pharmacology
    Mulawarman University School of Medicine
    Samarinda, East Kalimantan

Abstract :

Death caused by cardiovascular and cerebrovascular disease is still the highest. Atherosclerosis is due to hypercholesterolemia of predisposing factor of both diseases. Curcumin has antioxidant character that can inhibit lipid peroxidase to atherogenesis process. The aim of this study was to prove the effect of curcumin to decrease total cholesterol level, LDL-cholesterol level, the amount of F2-isoprostan and the formation of foam cell in aortic wall in rats receiving atherogenic diet. To determine the effect of curcumin to decrease total cholesterol level, LDL-cholesterol, the number of F2-isoprostan and foam cell in wistar strain white rats, atherogenic diet was given for 10 weeks into 6 groups (n=24): atherogenic diet group (control), atherogenic diet group + curcumin (50 mg/kg bw per day), atherogenic diet group + curcumin (100 mg/kg bw per day), atherogenic diet group + curcumin (200 mg/kg bw per day), atherogenic diet group + curcumin (400 mg/kg bw per day), normal diet group (control). After 10th weeks, total cholesterol level and LDL-cholesterol were measured by spectrophotometry. The number of F2-isoprostan and foam cell was counted semi quantitatively by light microscope. F2-isoprostan staining was done with immunohystochemistry Avidin Biotin Complex method, and foam cell staining with HE-oil Red O. The results showed that the highest total cholesterol level was found in group I (275.15 ± 10.01; mean ± SD), the highest LDL-cholesterol level found in group I (158.15 ± 12.19). Statistically, total cholesterol level and LDL-cholesterol level in group I were significantly higher (p = 0.05) than those in other groups. Total cholesterol level and LDL-cholesterol was found to decrease in group V (93.31 ± 4.07; 19.76 ± 5.25). The highest number of F2-isoprostan was found in group I (5.5 ± 1.29). The highest foam cell was found in group I (3.5 ± 1). Statistically, the number of F2-isoprostan and foam cell in group I were significantly higher (p = 0.05) than those in other groups. The number of F2-isoprostan and foam cell were found to decrease in group V (1 ± 0.82 ; 0.5 ± 0.58). In conclusion, curcumin has effect in decreasing total cholesterol level, LDL-cholesterol, number of F2-isoprostan and the formation of foam cell significantly in rats with atherogenic diet. The administration of curcumin in a dose of 400 mg/kg bw daily is more effective in decreasing total cholesterol level, LDL-cholesterol, number of F2-isoprostan and the formation of foam cell than in other 3 doses of curcumin.

Keyword :

curcumin, total cholesterol, LDL-cholesterol, F2-isoprostan, foam cell and atherogenic diet,


References :

M Ali,(2001) Vaksinasi LDL yang teroksidasi pada Aterosklerosis Fase Awal Malang : Brawijaya University School of Medicine

I Muliartha,(2001) Vaksinasi LDL yang teroksidasi pada Aterosklerosis Fase Awal Malang : Brawijaya University School of Medicine

S Muwarni,(2001) Vaksinasi LDL yang teroksidasi pada Aterosklerosis Fase Awal Malang : Brawijaya University School of Medicine

Araujo,(2001) Biological Activities of Curcuma Longa L no info : Mem Inst Oswaldo Cruz

LL Leon,(2001) Biological Activities of Curcuma Longa L no info : Mem Inst Oswaldo Cruz

R Arjuna,(2002) F2-isoprostan Sebagai Prediktor Dini Disfungsi Endotel Akibat Dislipidemia Surabaya : Airlangga University Postgraduate Program

PS Babu,(1997) Hypolipidemic Action of Curcumin, the Active Principle of turmeric (curcuma longa) in streptozotocin induced diabetic rats no info : Mol Cell Biochem

K Srinivasan,(1997) Hypolipidemic Action of Curcumin, the Active Principle of turmeric (curc



Archive Article

Cover Media Content

Volume : 43 / No. : 3 / Pub. : 2007-09
  1. A3243g Mitochondrial Dna Mutation Does Not Play An Important Role Among Dm Population In Indonesia
  2. Effect Of Curcumin On The Levels Of Total Cholesterol, Ldlcholesterol, The Amount Of F2-isoprostan And Foam Cell In Aortic Wall Of Rats With Atherogenic Diet
  3. Increase Of Immunoglobulin A Titer In Mice Intestinal Mucosa After Immunization With Toxoplasma Gondii Soluble Protein With And Without Intranasal Cholera Toxin Adjuvant
  4. Use Of Haematological And Immunological Biomarker As Indicator Of Pb Intoxication
  5. Correlation Between Birthweight And Bodyweight Increase Of Pregnant Women With Normal Body Mass
  6. Analysis Of The Risk Factors Of Pulmonary Edema In Preeclampsiaeclampsia In Dr Soetomo Hospital, Surabaya
  7. The Role Of Laparoscopy Surgery In Infertility
  8. Influence Of Lbw Formula Feeding On The Growth Of Low Birth Weight Infant
  9. Diagnosis Of Upper Urinary Tract Infection Using Streptavidin Biotin Test In Urine Sediment. A New Approach Using Immunohistochemical Test For Determining The Site Of Urinary Tract Infection
  10. Detection Of Dengue Virus Antigen In Monocytes To Support The Diagnosis Of Dengue Hemorrhagic Fever
  11. Drug Utilization Profile In Hiv/aids Patients. Study At Dr Soetomo Teaching Hospital Surabaya

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