UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 3 / Published : 2014-07

Order : 9, and page :179 - 186

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Original Article :

Effect of g-csf on anc level in all (acute lymphoblastic leukemia) patient with neutropenia and febrile neutropenia during chemotherapy

Author :

  1. Siti Nur Asiyah*1
  2. Bambang Permono*2
  3. Yulistiani*3
  4. Mariyatul Qibtiyah*4
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Farmasi
  3. Pharmacy Unit, Dr. Soetomo Hospital, Surabaya
  4. Pharmacy Unit, Dr. Soetomo Hospital, Surabaya

Abstract :

Acute Lymphoblastic Leukemia (ALL) is the most common malignancy in children. Chemotherapy-induced neutropenia (CIN) is oneof the serious adverse events that may cause complication such as febrile neutropenia. Neutrophils level is increased using G-CSF,whose effectiveness based on ANC (absolute neutrophil counts) pre and post G-CSF therapy level remains unknown. This study wasto analyze the ANC level changes pre and post G-CSF therapy in neutropenia and febrile neutropenia patients with standard risk andhigh risk chemotherapy protocol. This was a retrospective-observational study from January 2010 to December 2013. Pre-therapyANC level had been collected before receiving G-CSF therapy. Post-therapy ANC level was collected between day 1 to 7 aftertherapy discontinuation. Data were analyzed using paired t-test to determine ANC level changes pre- and post-therapy. Range of GCSFdose of neutropenia vs febrile neutropenia patient with SR protocols therapy was 9.172 ± 1.5646 vs 9.079 ± 1.646 μg/kgBW,and for HR protocols 9.909 ± 1.1229 vs 9.114 ± 1.8551 μg/kgBW/day. In conclusion, G-CSF in a dose of 5-10 μg/kgBW per dayincreases ANC level significantly in ALL patients with neutropenia under high risk and standard risk protocol and in ALL patientswith febrile neutropenia under standard risk protocol. However, the increase of ANC level is not significant in ALL patients withfebrile neutropenia under high risk protocol. (FMI 2014;50:179-186)

Keyword :

chemotherapy induced neutropenia, acute lymphoblastic leukemia, pediatric, G-CSF,


References :

Crawford J, Dale DC, Lyman GH,(2004) Chemotherapy-induced neutropenia: risks, consequences, and new directions for its management 100, 228-237 : Cancer

Fortner BV, Houts AC, Schwartzberg LS,(2006) A prospective investigation of chemotherapy-induced neutropenia and quality of life 4, 472-478 : J Support Oncol





Archive Article

Cover Media Content

Volume : 50 / No. : 3 / Pub. : 2014-07
  1. Heavy Metal Contamination May Have A Role In Negative Correlation Between Seafood Consumption And Visuo-motor Development Of 1-3 Year-old Children In Subdistrict Bulak, Surabaya
  2. Detection Of Gyra Gene Mutation Region In Fluoroquinolone Resistant Mycobacterium Tuberculosis Isolate From Surabaya Indonesia
  3. Intravenous Vitamin C Administration Decreases Nitric Oxide Serum Level In Severe Burn Injury
  4. The Overview Of Macrophage, Mast Cell, And Lymphocyte Activity In The Efficacy Distinction Of Pain Reduction For Dry And Wet Cupping Therapies
  5. Effectiveness Of Fosfomycin On Prevention Of Surgical Site Infection Of Closed Brain Injury Patients After Craniotomy In Emergency Unit Dr. Soetomo Hospital
  6. Soot Particulate Matter Exposure Increases Interleukin 6 Levels In The Mechanism Of Cardiovascular Disorders
  7. Electric Shock Increases Vcam And Mcp In Mice Endothelial Blood Vessel
  8. Magnesium And Potassium Parenteral Supplementation Does Not Produce Significant Effect On Magnesium And Potassium Serum Level Of Cervical Cancer Patients Receiving Cisplatin Chemotherapy
  9. Effect Of G-csf On Anc Level In All (acute Lymphoblastic Leukemia) Patient With Neutropenia And Febrile Neutropenia During Chemotherapy
  10. Comparative Effectiveness Of Paracetamol And Metamizol As Antipyretics In Patients With Moderate And Severe Brain Injury In Dr. Soetomo Hospital, Surabaya
  11. Analysis Of Complicated Factors Affecting Therapy Effectiveness In Urinary Tract Infections
  12. In Infant With Acute Diarrhea, Nutritional Status Has Correlation With Dehydration Degree, But Not With Mother’s Education And Breastfeeding
  13. The Use Of Antibiotics In Patients With Urinary Tract Infection

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