UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

Order : 1, and page :216 - 223

Related with : Scholar   Yahoo!   Bing

Original Article :

Genetic variation of g6pd and adaptive phenomena in malarial infection

Author :

  1. Indah S Tantular*1
  1. Department. of Parasitology, Airlangga University School of Medicine

Abstract :

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-chromosome-linked hereditary abnormality with a high degree of clinical, biological and genetic variations. Some people are born with a mutation of the G6PD gene, which, when reacting to certain triggers, such as infection, some drugs like anti-malarials drug or some foods such as fava beans, can cause anemia. But those same people also seem more able to resist the worst effects of malaria. More than 300 G6PD variants have been defined, most common are those variants associated with acute intermittent hemolytic anemia. The geographic distribution of populations with a high gene frequency of deficient variants overlaps closely with the prevalence of malaria, suggesting that G6PD deficiency might be protective against malaria. Evidence for a protective affect of G6PD deficiency against Plasmodium falciparum comes from both epidemiological correlation and in vitro studies. Malaria is a major killer worldwide with high mortality rates among children. Of the four common malarial parasites in humans, P. falciparum is the deadliest. There are hundreds of million cases due to other parasite species: P. vivax, P. malariae and P. ovale. The risk of malaria transmission in endemic countries is increased in rural areas and varies seasonally in many locations.

Keyword :

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency, Malaria, G6PD variant, Indonesia,


References :

Beutler, E, Yeh, M, Fairbanks, VF,(1962) The normal human female as a mosaic of X-chromosome activity, Studies using the gene for G6PD deficiency as a marker - : Proc Natl Acad Sci USA

Damanik, SM, Ugrasena, IDG, Harianto, A et al.,(2001) Mass screening of G6PD in Dr Soetomo General Hospital - : Folia Medica Indonesiana

Hirono, A, Ishii, A, Kere, N, Fujii, H et al,(1995) Molecular analysis of glucose-6-phosphate dehydrogenase variants in the Solomon Islands - : Am J Hum Genet





Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2008-10
  1. Genetic Variation Of G6pd And Adaptive Phenomena In Malarial Infection
  2. Molecular Analysis Of The Coding Sequence Of Mage-1 Gene From Hepatocelular Carcinoma Patient And Testis
  3. Potential Value Of C-reactive Protein As Inflammation Marker And Il-1β, Tnf- As Pro-inflammatory Cytokine On Disease Activity Of Rheumatoid Arthritis
  4. Cell Surface Her2/neu Oncoprotein Expression In Breast Ductal Carcinoma
  5. Difference In The Productivity Of B-lymphocyte Isolated From Lymph Nodes And That Isolated From Mice Spleen In The Production Of Toxocara Cati Monoclonal Antibody Using Hybridoma Technology
  6. Exploration In The Use Of Medicinal Plant Acanthus Ilicifolius L In The Treatment Of Endothelial Dysfunction
  7. Detection Of M. Tuberculosis And Drug Sensitivity Test From Sputum Culture Of Pulmonary Tuberculosis Patients In Dr Soetomo General Hospital Between 2003-2004
  8. The Pharmacokenetics Of Levofloxacin In Healthy Rabbit Treated With Antacid
  9. Potency Of Lactobacillus Reuteri On Reduced Inflammation In Septic Encephalopathy
  10. Pharmacokinetic Parameters Determination Of A Single 500-mg Oral Dose Of Levofloxacin In Healthy Subjects By Using Blood Data
  11. Encephalopathy And Neuroendocrine Disorder In Septic Shock
  12. Osteoarthritic Pain Treatment With Electroacupuncture
  13. Review Article And Clinical Experience: Astaxanthin – Oxidative Stress – Diabetes Mellitus From Basics To Clinics And From General To Specific

Information index.php/JIPK/tmp_tumb/FMI