UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 3 / Published : 2010-07

Order : 2, and page :167 - 171

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Original Article :

Glomerular filtration rate in liver cirrhosis

Author :

  1. Titong Sugihartono*1
  2. Iswan A Nusi*2
  3. Poernomo Boedi S*3
  4. Hernomo O Kusumobroto*4
  5. Umar K*5
  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Airlangga School of Medicine, Dr. Soetomo Hospital Surabaya
  2. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Airlangga School of Medicine, Dr. Soetomo Hospital Surabaya
  3. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Airlangga School of Medicine, Dr. Soetomo Hospital Surabaya
  4. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Airlangga School of Medicine, Dr. Soetomo Hospital Surabaya
  5. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Airlangga School of Medicine, Dr. Soetomo Hospital Surabaya

Abstract :

Liver cirrhosis (LC) is often accompanied by functional renal failure. The mortality was significantly greater in LC patients with creatinine clearance less than 50 ml/min. Indicators of moderately impaired renal function are of great clinical importance. Serum creatinine concentration, the best establish simple parameter of glomerular filtration rate (GFR), has some disadvantages: its concentration depends on sex and muscle mass and shows marked increases only at severely reduced creatinine clearance values. Cystatin C has recently been suggested as a sensitive marker of GFR and as early indicator of impaired renal function. Cystatin C serum concentration appears to be independent of sex and muscle mass. The determination of cystatin C is not affected by billirubun or haemolysis. The objective of this study was to investigate the correlation between GFR (based on cystatin C levels) and hepatic index in patients with LC at Dr. Soetomo Hospital.This study used cross-sectional design, involving population of liver cirrhosis patients who had eligible inclusion and exclusion criteria. It was found that GFR (based on cystatin C levels) in patients with LC with mild hepatic failure is 60.625 ± 17.631, moderate hepatic failure is 50.231 ± 12.029, and severe hepatic failure 16.960 ± 8.438. There was a strong negative correlation between GFR (based on cystatin C levels) and hepatic index based on score levels (r -0.646; 0.0001) and based on stadium levels (r -0.636; p 0.001) in LC patients. In conclusion, based on cystatin C serum level, GFR in patients LC with mild hepatic failure higher than those in moderate hepatic failure and severe hepatic failure. GFR does not play a major role in determining hepatic index. Nevertheless, GFR in patients LC with mild hepatic failure higher than those in moderate hepatic failure and severe hepatic failure.

Keyword :

glomerular filtration rate, cystatin C, liver cirrhosis,


References :

Arroyo V, Gines P, Jimenez W et al,(1999) Renal dysfunction in cirrhosis. In: Bircher L, Benhamou JP, McIntyre N, et al, eds. Oxford textbook of clinical hepatology New York : Oxford University Press

Whelton A, Watson AJ, Rock RC,(1994) Nitrogen metabolites and renal function. In, Burtis CA, Ashwood ER, eds. Tietz textbook of clinical chemistry Philadelphia : WB Saunders

Arroyo V, Gines P, Gerbes AL, et al,(1996) Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis - : Hepatology





Archive Article

Cover Media Content

Volume : 46 / No. : 3 / Pub. : 2010-07
  1. Socioeconomic And Genetic Factors Influencing The Strength, Weight, Length And Width Measurements Of Children
  2. Glomerular Filtration Rate In Liver Cirrhosis
  3. Antimicrobial Activity Of Mahkota Dewa [phaleria Macrocarpa (scheff). Boerl.] Leaf Extract Against Pseudomonas Aeruginosa By Agar Dilution And Scanning Electron Microscopy
  4. Mapping Pattern Of Core Dna Loci In Forensic Identification Sample Examination Using Polymerase Chain Reaction (pcr) In Loci Csf1po, Tho1 And Tpox
  5. Spatial Analysis Of Dengue Fever Regarding Its Determinant Factors In Bandar Lampung
  6. Inhibition Of The Mitogen Activated Protein Kinase (mapk) In The Inflammatory Pain Like State Using Sb 203580 And Pd 98059 In Mice
  7. Cloning Of Melanoma Antigen-1 (mage-1) Gene From Fine Needle Aspiration Biopsy Of Hepatic Tissue Of Hepatocelluler Carcinoma Patients
  8. Detection Of Urinary Incontinence Affecting Post-menopausal Age Using Ii Q-7 And Udi-6 Questionnaire At Immanuel Teaching Hospital Bandung
  9. Electron Microscopic Scanning Profile Of Balb/c Mice Intestinal Villi After Per Oral Lps (lipopolysaccharide) During Probiotic Induction
  10. Extensive Intensity Exercise Most Effectively Increases Anaerobic Threshold
  11. Pegagan (centella Asiatica) Extract Increases Vaginal Wall Thickness In Menopausal Rats
  12. Review Article: Interval Exercise With 1:1 Work/rest Ratio Decreases The Risk Factors Of Type-2 Diabetes Mellitus And Coronary Heart Disease
  13. Expression Of Topoisomerase Iiα And Cyclin D1 Proteins In Various Degrees Of Breast Ductal Carcinoma

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