UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 46 / No. 4 / Published : 2010-10

Order : 14, and page :303 - 306

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Original Article :

Hormonal status (estrogen receptors - progesterone) and her-2 neu in various cyclin d1 expressions in breast cancer

Author :

  1. Imam Susilo*1
  2. Imelda Theodora*2
  3. Nila Kurniasari*3
  1. Department of Anatomic Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Teaching Hospital, Surabaya
  2. Department of Anatomic Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Teaching Hospital, Surabaya
  3. Department of Anatomic Pathology, Faculty of Medicine, Airlangga University, Dr. Soetomo Teaching Hospital, Surabaya

Abstract :

Breast cancer is the most common malignancy and leading death cause of malignancy in women in the world. Expression of estrogen receptors (ER) and progesterone receptors (PR) has long been used to determine endocrine therapy patients. Family of human epidermal growth factor receptor, namely (HER-2/neu) has been used as markers to predict prognosis and therapy response. But many ductal breast carcinoma patients showed expression of ER, PR, and HER-2 neu negative (triple negative tumors). There should be further research for patients with triple negative tumors, to find prognostic markers and therapies. The purposed of this study was to analyze the relationship between hormonal status and HER-2 expression with cyclin D1expression in breast ductal carcinoma. This study was an observational analytic study, conducted at the Department of Pathology Faculty of Medicine Airlangga University/Dr. Soetomo. Paraffin blocks of 35 patients with invasive ductal breast carcinoma, which has not been treated with anti-cancer drug, in a variety hormonal status and HER-2 neu expression, followed by immunohistochemical examination. The results obtained, 31.4% patients in the age group 50 to 59 years. Cyclin D1 positive expression in 54.3% samples, and positive in 87.5% samples with ER positive and negative in 55.6% samples with negative ER. In positive PR sample, cyclin D1 positive in 72.7% samples, and cyclin D1 negative in 54.2% samples with negative PR.. Also showed that cyclin D1 positive in 85.7% samples with HER-2 positive and negative in 66.7% samples with HER-2 negative. In conclusion, there is a positive correlation between expression of ER and HER-2 neu by cyclin D1 expression.

Keyword :

breast cancer, ER, PR, HER-2 neu, cyclin D1,


References :

Bilalovic N, Vranic S, Basic H et al.,(2005) Immunohistochemical evaluation of cyclin D1 in breast cancer - : Croat Med

Chodosh LA,(2002) Clinical implications of basic research: the recripocal dance between cancer and development - : New England Journal of Medicine

Holley S, Parkers G, Matthias C, Bockmuhl U, Jahnke V, Ledder K, Strange CR, Fryer AA, Hobban PR,(2001) Cyclin D1 polymorphism and expression in patients with squamous cell carcinoma of the head and neck - : American Journal of Pathology





Archive Article

Cover Media Content

Volume : 46 / No. : 4 / Pub. : 2010-10
  1. Contribution Of Lifestyle And Obesity To The Incidence Of Pre-diabetes
  2. The Importance Of Parenting On Growth And Development In Toddlers
  3. Combination Of Metformin And Hyperbaric Oxygen Therapy Increased Enos Concentration
  4. Description Of Blood Viscosity From Diabetes Mellitus Outpatients In Endocrine Clinic, Aw Sjahranie Hospital, 2009
  5. 2-methoxyethanol Exposure Affects Protein Profile Of Testicular Sperm Membrane In Mice (mus Musculus)
  6. Extract Of Psidium Guajava Leaves Reduces Malondialdehyde In Soleus Muscle Of Wistar Rats Directly After Acute Physical Activity
  7. Occupational Health And Safety Behavior Analysis And Nosocomial Infection Risk In Cleaning Service Workers At Dr. Seotomo Hospital Surabaya
  8. Groundstroke Exercise Combined With Jogging Can Increase The Physical Fitness Of Tennis Players
  9. Hematocrite As A Screening Test Of Iron Deficiency Occurrence In Tetralogy Of Fallot
  10. Comparison Of Maternal Zinc Level In Term Pregnancy Associated With Premature Rupture Of Membranes In Normal Pregnancy
  11. Predominance Of Right Hemisphere In Post-ischemic Stroke Immunity Modulation
  12. Screening In Proteinuria-hematuria Among 5 - 26 Years Old Students In Closed Community School In Surabaya, Indonesia
  13. Non-specific Pattern Of Ultrasonogram (usg) In Lymphoma Of The Breast
  14. Hormonal Status (estrogen Receptors - Progesterone) And Her-2 Neu In Various Cyclin D1 Expressions In Breast Cancer

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