UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 3 / Published : 2012-07

Order : 2, and page :96 - 101

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Original Article :

In vitro antimalarial activity of belimbing wuluh (averrhoa bilimbi) leaves extract on plasmodium falciparum

Author :

  1. Abdul Mughni*1
  2. Indah S. Tantular*2
  3. Eka Prasetya Budi Mulia*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Mahasiswa Fakultas Kedokteran

Abstract :

Bilimbi (Averrhoa bilimbi) as the tropical plants that grow in Indonesia is still not widely used. Traditionally, the use of bilimbi to treat hypertension and diabetes mellitus has been scientifically proven. The contents of bilimbi leaves composed of several kinds of flavonoids that posses variety of roles in biological life. One of flavonoid that is much available is luteolin. In this experiment, the methanol extract of the leaves is tested for the growth of Plasmodium falciparum by in vitro test in order to know the anti malarial activity of the bilimbi leaves. IC50 is used as the indicator of anti malarial activity by statistical analysis using SPSS 17. The test is done by two replication and the result of IC50 is 2,805 μg/ml. This number indicates that the methanol extract of bilimbi (Averrhoa bilimbi) leaves is prospective as the anti malarial herbal medicine that states IC50 < 50 μg/ml of the crude extract inhibition activity is prospective. This methanol extract is included in good activity criteria with IC50<10 μg/ml. (FMI 2012;48:96-101)

Keyword :

Methanol extract, bilimbi leaves, Plasmodium falciparum, anti malaria,


References :

Hoffman SL,(1986) Clinics in Tropical Medicine and Communicable Diseases Malaria: Treatment of Malaria Philadelphia : WB Saunders Company

Dolabela MF, Oliveira SG, Nascimento JM, Peres JM, Wagner H, Póvoa MM, de Oliveira AB,(2008) In vitro antiplasmodial activity of extract and constituents from Esenbeckia febrifuga, a plant traditionally used to treat malaria in the Brazilian Amazon - : Phytomedicine





Archive Article

Cover Media Content

Volume : 48 / No. : 3 / Pub. : 2012-07
  1. In Vitro Intraerythrocytic Antimalarial Activity Of Akar Kuning (arcangelisia Flava (l.) Merr.) Stem Aqueous Extract In Plasmodium Falciparum
  2. In Vitro Antimalarial Activity Of Belimbing Wuluh (averrhoa Bilimbi) Leaves Extract On Plasmodium Falciparum
  3. Effect Of Earthworms (lumbricus Sp.) Extract Antibacterial Activity Against The Bacteria Salmonella Typhii
  4. In Vitro Antibacterial Activities Of Commercial Probiotic Drinks Against Salmonella Typhii
  5. Essential Oil Extract Of Citrus Aurantifolia L. Has Better Antibacterial Effect Than Sulfur Towards Staphylococcus Epidermidis
  6. Benzalkonium Chloride And Pine Oil-containing Cleaning Fluid Is Not Effective Against Pseudomonas Aeruginosa
  7. Mrsa-carrier Detection In Semester-1 Students Of Medical Doctor Program, Faculty Of Medicine, Airlangga University, Surabaya, Class 2009
  8. Preterm Birth And The Affecting Factors In Dr. Soetomo Hospital, Surabaya, Indonesia
  9. Effect Of Type-2 Diabetes Mellitus On Cataract Incidence Rate At Ophthalmology Outpatient Clinic, Dr Soetomo Hospital, Surabaya

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