UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 3 / Published : 2012-07

Order : 1, and page :90 - 95

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Original Article :

In vitro intraerythrocytic antimalarial activity of akar kuning (arcangelisia flava (l.) merr.) stem aqueous extract in plasmodium falciparum

Author :

  1. Ramadhani RB*1
  2. Heny Arwati*2
  3. Eric Robhets Lovin*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Mahasiswa Fakultas Kedokteran

Abstract :

Akar kuning (Arcangelisisa flava (L.) Merr) has been used as hereditary traditional medicine in many regions of Indonesia for treating various diseases, one of which is malaria. Generally, traditional communities use the stem of this plant for treating malaria. The aqueous extract of stem of this plant has been used on this study to test the antimalarial activity against Plasmodium falciparum 3D7 strain in vitro. After 48 hours incubation, the parasitemia has been calculated based on Giemsa-stained thin smears of the extract-treated culture, positive control, and negative controL. Parasitemia percentage was determined within 1000 red blood cells, and used to calculate the growth percentage and inhibitory percentage. Based on the inhibitory percentage, IC50 was determined by means of SPSS 17 program. The results indicate that the aqueous extract of this plant posses antimalarial activity against the growth of P. falciparum 3D7 strain and the IC50 of the extract was 1.811 μg/mL. (FMI 2012;48:90-95)

Keyword :

Aqueous extract, in vitro, Arcangelisisa flava (L.) Merr, Plasmodium falciparum, Antimalarial activity,


References :

Bloland PB,(2001) Drug Resistance in Malaria Switzerland : World Health Organization

Ariyanti EE,(2001) Mengenal sirawan (Arcangelisia flava L. Merr), tumbuhan langka yang berkhasiat obat - : Warta Kebun Raya





Archive Article

Cover Media Content

Volume : 48 / No. : 3 / Pub. : 2012-07
  1. In Vitro Intraerythrocytic Antimalarial Activity Of Akar Kuning (arcangelisia Flava (l.) Merr.) Stem Aqueous Extract In Plasmodium Falciparum
  2. In Vitro Antimalarial Activity Of Belimbing Wuluh (averrhoa Bilimbi) Leaves Extract On Plasmodium Falciparum
  3. Effect Of Earthworms (lumbricus Sp.) Extract Antibacterial Activity Against The Bacteria Salmonella Typhii
  4. In Vitro Antibacterial Activities Of Commercial Probiotic Drinks Against Salmonella Typhii
  5. Essential Oil Extract Of Citrus Aurantifolia L. Has Better Antibacterial Effect Than Sulfur Towards Staphylococcus Epidermidis
  6. Benzalkonium Chloride And Pine Oil-containing Cleaning Fluid Is Not Effective Against Pseudomonas Aeruginosa
  7. Mrsa-carrier Detection In Semester-1 Students Of Medical Doctor Program, Faculty Of Medicine, Airlangga University, Surabaya, Class 2009
  8. Preterm Birth And The Affecting Factors In Dr. Soetomo Hospital, Surabaya, Indonesia
  9. Effect Of Type-2 Diabetes Mellitus On Cataract Incidence Rate At Ophthalmology Outpatient Clinic, Dr Soetomo Hospital, Surabaya

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