UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 1 / Published : 2013-01

Order : 3, and page :12 - 15

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Original Article :

Induced abortion at midgestation of sheep by stress

Author :

  1. Paul S Poli*1
  1. Department of Physiology Wijaya Kusuma University School of Medicine Surabaya, Indonesia

Abstract :

Stress and abortion were the beginning and end of an event i.e abortion. The aim of this experiment was to show that stress enforced body to produce cortisol in orther to overcome the stress itself while will caused abortion in pregnant ewe. Based on this aim, the hypothesis was cortisol will push the expression progesterone receptor A (PRA) and receptor estrogen-a (RE- a) in uterine myometrium which produced uterine contraction and abortion. In order to test the hypothesis, I’ll use the synthetical cortisol, dexamethasone as a stressor. Of 21 healthy pregnant sheep were grouping by random allocation into three groups each consist of 7 animal at the pregnant age 70-90 days. The control group were inject with normal saline 0,9% intramuscular (i.m), while treatment group divide into 2 group for intramuscular (i.m) injection of low and high dose of dexamethasone 4 mg and 8 mg. Peripheral blood were taken for estrogen and progesterone analysis by radioimmunoassay and uterine specimen for progesterone receptor A, as well as estrogen receptor a expression by using immunohistochemistry preparation. High significantly were obtained among the treatment and control group, conversely the concentration of estrogen and progesterone were decline.  In conclusion, it seems like that stress through cortisol production had encouraged abortion among the midpregnant sheep through the progesterone receptor A expression. (FMI 2013;49:12-15)

Keyword :

stress, dexamethasone, PR-A, ER, abortion,


References :

Mesiano S,(2004) Myometrial progesterone responsiveness and the control of human parturition - : J Soc Gynecol Investig

Pieber D, Allport VC, Hills F, Johnson M, Bennett PR,(2001) Interactions between progesterone receptor isoforms in myometrial cells in human labour - : Mol Hum Reprod





Archive Article

Cover Media Content

Volume : 49 / No. : 1 / Pub. : 2013-01
  1. The Effect Of Emotional Quality Management On Cortisol, Tnf-, And Il-2 In Women With Breast Cancer
  2. Reduced Addiction In Drugs Abusers Undergoing Dhikr At Ponpes Inabah Xix Surabaya
  3. Induced Abortion At Midgestation Of Sheep By Stress
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