UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 3 / Published : 2014-07

Order : 3, and page :143 - 147

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Original Article :

Intravenous vitamin c administration decreases nitric oxide serum level in severe burn injury

Author :

  1. Iswinarno Doso Saputro*1
  2. Lobredia Zarasade*2
  3. Bobby Swadharma Putra*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Nitric oxide (NO) may cause systemic hypotension and apoptosis, contributing to tissue damage and multiple organ failure in severeburn, which increases Nitric Oxide Syntase (NOS) enzyme activity and NO release. Proinflammatory cytokines involves in NOSinduction and activation and NO release. Vitamin C suppresses proinflamatory cytokines production, so NO production is inhibited.This study aimed to review intravenous vitamin C 3000 mg effect on NO serum level in severe burn injury. This study usedrandomized pre-test and post-test controlled group design in 12 severe burns patient at Burn Unit, Dr. Soetomo Hospital, Surabaya.NO was examined in 12 patients who were divided into 2 groups. Control group (K1) received vitamin C 2 x 400 mg/24 hour for 72hours and treatment group (K2) received intravenous vitamin C 3000 mg for 72 hours. NO was taken from blood serum andobserved by Grease method. Results were analyzed by Paired T-Test and statistical assays with p < 0.05. NO serum level in K1showed no significant increase compared to day 1 of the day 4 (p = 0.21) and NO serum level had no significant decrease on day 1than that on day 4 (K2) (p = 0.06). NO level decreased significantly in K2 compared to that in K1 (p = 0.02). K1 showed nosignificant result in Blood Gas Analisis, Blood Urea Nitrogen, and Serum Creatinine, while K2 showed significant result in WhiteBlood Cell (p = 0.01). In conclusion, intravenous vitamin C administration decreases nitric oxide serum level in severe burn injury.(FMI 2014;50:143-147)

Keyword :

vitamin C, severe burn, nitric oxide,


References :

Çakir B and Yeğen BC,(2004) Systemic responses to burn injury 34, 215-226 : Turk J Med Sci

Chen LW, Hsu CM, Cha MC, Chen JS, Chen SC,(1999) Changes in gut mucosal nitric oxide synthase (NOS) activity after thermal injury and its relation with barrier failure 11, 104-110 : Shock





Archive Article

Cover Media Content

Volume : 50 / No. : 3 / Pub. : 2014-07
  1. Heavy Metal Contamination May Have A Role In Negative Correlation Between Seafood Consumption And Visuo-motor Development Of 1-3 Year-old Children In Subdistrict Bulak, Surabaya
  2. Detection Of Gyra Gene Mutation Region In Fluoroquinolone Resistant Mycobacterium Tuberculosis Isolate From Surabaya Indonesia
  3. Intravenous Vitamin C Administration Decreases Nitric Oxide Serum Level In Severe Burn Injury
  4. The Overview Of Macrophage, Mast Cell, And Lymphocyte Activity In The Efficacy Distinction Of Pain Reduction For Dry And Wet Cupping Therapies
  5. Effectiveness Of Fosfomycin On Prevention Of Surgical Site Infection Of Closed Brain Injury Patients After Craniotomy In Emergency Unit Dr. Soetomo Hospital
  6. Soot Particulate Matter Exposure Increases Interleukin 6 Levels In The Mechanism Of Cardiovascular Disorders
  7. Electric Shock Increases Vcam And Mcp In Mice Endothelial Blood Vessel
  8. Magnesium And Potassium Parenteral Supplementation Does Not Produce Significant Effect On Magnesium And Potassium Serum Level Of Cervical Cancer Patients Receiving Cisplatin Chemotherapy
  9. Effect Of G-csf On Anc Level In All (acute Lymphoblastic Leukemia) Patient With Neutropenia And Febrile Neutropenia During Chemotherapy
  10. Comparative Effectiveness Of Paracetamol And Metamizol As Antipyretics In Patients With Moderate And Severe Brain Injury In Dr. Soetomo Hospital, Surabaya
  11. Analysis Of Complicated Factors Affecting Therapy Effectiveness In Urinary Tract Infections
  12. In Infant With Acute Diarrhea, Nutritional Status Has Correlation With Dehydration Degree, But Not With Mother’s Education And Breastfeeding
  13. The Use Of Antibiotics In Patients With Urinary Tract Infection

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