UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 1 / Published : 2009-01

Order : 6, and page :28 - 31

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Original Article :

Isolation of male antifertility compound in n-butanol fraction of justicia gendarussa burm. f. leaves

Author :

  1. Bambang Prajogo EW*1
  2. David Guliet *2
  3. Ferreira Queiroz E*3
  4. John-Luc Wolfender*4
  5. Noor Cholies Z *5
  1. Department of Nature Product, Faculty of Pharmacy Airlangga University, Surabaya, Indonesia
  2. Institute of Pharmacognosy and Phytochemistry, University of Lausanne, Switzerland
  3. Institute of Pharmacognosy and Phytochemistry, University of Lausanne, Switzerland
  4. Institute of Pharmacognosy and Phytochemistry, University of Lausanne, Switzerland
  5. Department of Nature Product, Faculty of Pharmacy Airlangga University, Surabaya, Indonesia

Abstract :

The isolation has been done on major compound of Justicia gendarussa Burm.f. (Acanthaceae) leaves, it used as male contraceptive in Papua as ethno medicine. Preclinical study showed activity as a male contraceptive. First information, J. gendarussa was known containing flavonoid beside alkaloid, steroid and mineral. Extraction used by percolation method with n-hexane, methanol, chloroform and n-butanol successively. Isolation and separation were done by column chromatography (silica, diaion and sephadex), MPLC and preparative HPLC. For the analyzing purpose, TLC, LC-UV and LC-MS were used. For the structure elucidation, 1H-13C NMR Inova 500 Mhz was used. Major compounds is 6,8-di-C-beta-L-arabinopyranosyl-4’,5,7-trihydroxyflavone or 6,8-di-C-beta-L-arabinosyl-apigénine. Minor compounds is 6-C-beta-L-arabinopyranosyl-4’,5,7-trihydroxy-8-C-beta-D-ylopiranosyl-flavone or 6-C-beta-L-arabinosyl-8-C-beta-D-xylosyl-apigenine. Nevertheless that compounds were not the novel compound, but this is for the first time known in J. gendarussa, so names proposed for both compound were gendarusin A and gendarusin B.

Keyword :

Justicia gendarussa, flavone, apegenine, male contraceptive,


References :

Hegnauer,(1964) Chemotaxonomie der Pflanzen, Band III Basel und Stutgart : Birkhauser Verlag

Moeso, S and Agus,P,(1985) Report of The Trip to Jayapura Sentani (Irian Jaya) Yogyakarta : Faculty of Biology Gadjah Mada University





Archive Article

Cover Media Content

Volume : 45 / No. : 1 / Pub. : 2009-01
  1. Comparison Of Acid-base Balance Change In Hypovolemic Shock With 0.9% Normal Saline Therapy And Ringers Lactate. A Controlled Randomized Clinical Test
  2. The Effectiveness Of Acid Phosphatase And Zinc Tests On The Seminal Fluid Spot Examination As The Primary Identification. A Laboratory Observational Study
  3. The Relationship Between The Width And That Of Dental Arch Of The Upper Jaw In Patients With Down’s Syndrome Which Is Measured By Anthropometric Methods
  4. Immuno-modulatory Effect Of Probiotic And Sublingual Immunotherapy In Asthmatic Children
  5. Difference Of Plasma Interleukin-10 Level In Pulmonary Tuberculosis Patients And Healthy Nurses With Pulmonary Tuberculosis Risk
  6. Isolation Of Male Antifertility Compound In N-butanol Fraction Of Justicia Gendarussa Burm. F. Leaves
  7. Lps Helicobacter Pylori Causative Agent Of The Increase Of Tnf-α, Vcam, E-selectin And Mmp-8 As Indicator Of Endothelial Dysfunction
  8. Hyaluronan, Tnf-α And Estradiol Concentrations In Infertile Women With Endometriosis
  9. Factors Affecting Compliance To Medication In Lung Tuberculosis Patients
  10. Antiseizure And Neurotoxicity Effects Of Ligustrosid Glycoside Isolated From Fraxinus Graffithii Clarke Compared To Phenytoin And Diazepam
  11. Effect Of Andrographis Paniculata Extract On Mammary Carcinoma In Rats Induced By Dmba
  12. Review Article: Ultrasound Elastography: Development Of The Imaging Technique For Tissue Elasticity Assessment
  13. Review Article And Clinical Experience: Thyroid Storm: Quick Diagnosis And Quick Treatment. The Roles Of Formulas G/o–p-39.5 – 120 And Cs-7.1.5

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