UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 45 / No. 1 / Published : 2009-01

Order : 7, and page :32 - 40

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Original Article :

Lps helicobacter pylori causative agent of the increase of tnf-α, vcam, e-selectin and mmp-8 as indicator of endothelial dysfunction

Author :

  1. Heru Koesbijanto*1
  1. Department of Surgery Airlangga University School of Medicine Dr Soetomo Hospital, Surabaya

Abstract :

Objective of the study: Analyzing the transformation that occurs in the experimental animal’s endothelium infected by Helicobacter pylori. Cytokine which has a role in endothelial dysfunction will be analyzed and comparison between the experimental animal that has been infected by Helicobacter pylori and the experimental animal that is not infected by Helicobacter pylori was pursued. Method of the study: The research is categorized as Experimental research using Rattus norvegicus as an object of research. It consists of two group. First group is a control group and the second one is intramuscularly induced by LPS Helicobacter pylori three times with 3-day interval. Afterward, the indicator of endothelial dysfunction, TNF-alpha, e-selectin, MMP-8 and VCAM will be analyzed by using method of immunohistochemistry. The result of research: After conducting the Mann-Whitney T-Test and Spearman’s Rho Correlation Test, it is concluded that there is significant difference between the control group and the group with treatment (TNF-alpha, p=0,001, VCAM, p=0,008, MMP-8, p=0,00, e-selectin, p=0,008). It can be seen that there is a good correlation between TNF-alpha and e-selectin. Conclusion: LPS Helicobacter pylori encouraged lesion in arterial endothelium and finally causes atherosclerosis.

Keyword :

LPS Helicobacter pylori, Endothelial dysfunction, Inflammation, Infection,


References :

Darnell J., Lodish H., Baltimore D,,(1990) Molecular Cell Biology, 2nd edition New York : Scientific American Book

Kuby,(2000) Immunology, 4th edition New York : W.H. Freeman and Company





Archive Article

Cover Media Content

Volume : 45 / No. : 1 / Pub. : 2009-01
  1. Comparison Of Acid-base Balance Change In Hypovolemic Shock With 0.9% Normal Saline Therapy And Ringers Lactate. A Controlled Randomized Clinical Test
  2. The Effectiveness Of Acid Phosphatase And Zinc Tests On The Seminal Fluid Spot Examination As The Primary Identification. A Laboratory Observational Study
  3. The Relationship Between The Width And That Of Dental Arch Of The Upper Jaw In Patients With Down’s Syndrome Which Is Measured By Anthropometric Methods
  4. Immuno-modulatory Effect Of Probiotic And Sublingual Immunotherapy In Asthmatic Children
  5. Difference Of Plasma Interleukin-10 Level In Pulmonary Tuberculosis Patients And Healthy Nurses With Pulmonary Tuberculosis Risk
  6. Isolation Of Male Antifertility Compound In N-butanol Fraction Of Justicia Gendarussa Burm. F. Leaves
  7. Lps Helicobacter Pylori Causative Agent Of The Increase Of Tnf-α, Vcam, E-selectin And Mmp-8 As Indicator Of Endothelial Dysfunction
  8. Hyaluronan, Tnf-α And Estradiol Concentrations In Infertile Women With Endometriosis
  9. Factors Affecting Compliance To Medication In Lung Tuberculosis Patients
  10. Antiseizure And Neurotoxicity Effects Of Ligustrosid Glycoside Isolated From Fraxinus Graffithii Clarke Compared To Phenytoin And Diazepam
  11. Effect Of Andrographis Paniculata Extract On Mammary Carcinoma In Rats Induced By Dmba
  12. Review Article: Ultrasound Elastography: Development Of The Imaging Technique For Tissue Elasticity Assessment
  13. Review Article And Clinical Experience: Thyroid Storm: Quick Diagnosis And Quick Treatment. The Roles Of Formulas G/o–p-39.5 – 120 And Cs-7.1.5

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