UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 50 / No. 3 / Published : 2014-07

Order : 8, and page :172 - 178

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Original Article :

Magnesium and potassium parenteral supplementation does not produce significant effect on magnesium and potassium serum level of cervical cancer patients receiving cisplatin chemotherapy

Author :

  1. Elisabeth Kasih*1
  2. Suhatno*2
  3. Yulistiani*3
  4. Muhammad Yahya*4
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Farmasi
  4. Pharmacy Unit, Dr. Soetomo Hospital, Surabaya

Abstract :

Cisplatin is a chemotherapeutic agent for cervical cancer patients receiving radiation as the main therapy. One of cisplatin’s sideeffects is electrolyte disturbance, which is decreasing magnesium and potassium level. However, the application of MgSO4 and KClparenteral supplementation effectiveness as the hypomagnesaemia and hypokalemia prophylaxis remained in question. This studywas to evaluate magnesium and potassium parenteral supplementation effectiveness on magnesium and potassium serum level incervical cancer patients receiving cisplatin 50 mg/m2. This was an observational study using cross-sectional method. The inclusioncriteria was IIB stage cervical cancer patients who were going to receive the fourth cycle. All patients (n=22 patients) received 1000cc normal saline (NS) hydration, but only patients in treatment group (n=11 patients) received MgSO4 (0.5 g) and KCl (10 mEq)supplementation together with post-chemotherapy hydration. Data obtained were magnesium, potassium, creatinine, and BUN serumconcentration, each was measured pre- and post-fourth cycle cisplatin chemotherapy. Results, in pre-fourth cycle control group,magnesium serum level was 1.87 ± 0.22 mg/dL while potassium was 4.15 ± 0.71 mmol/L. In post-fourth cycle, magnesium serum was1.75 ± 0.19 mg/dL while potassium was 4.21 ± 0.67 mmol/L. In pre-fourth cycle treatment group, magnesium serum was 1.95 ± 0.25mg/dL while potassium was 4.06 ± 0.36 mmol/L. In post-fourth cycle, magnesium serum was 1.85 ± 0.16 mg/dL while potassium was4.01 ± 0.28 mmol/L. In conclusions, both groups showed no significant difference in magnesium serum and in potassium levels. Noclinical manifestation hypomagnesaemia or hypokalemia appeared in any patient. (FMI 2014;50:172-178)

Keyword :

cisplatin, electrolyte disturbances, magnesium serum, potassium serum, supplementation,


References :

Anvari K, Toussi MS, Mirsadraee M,(2010) Evaluation of intravenous magnesium supplementation as prophylaxis for cisplatin-induced hypomagnesemia 1, 109-114 : Middle East J Cancer

Arunkumar PA, Mukund H, Radheshyam N, Belliyappa MS,(2011) Clinical evaluation of cisplatin induced nephrotoxicity characterized by electrolyte disturbances 1, 100-104 : Asian J Res Pharm Sci





Archive Article

Cover Media Content

Volume : 50 / No. : 3 / Pub. : 2014-07
  1. Heavy Metal Contamination May Have A Role In Negative Correlation Between Seafood Consumption And Visuo-motor Development Of 1-3 Year-old Children In Subdistrict Bulak, Surabaya
  2. Detection Of Gyra Gene Mutation Region In Fluoroquinolone Resistant Mycobacterium Tuberculosis Isolate From Surabaya Indonesia
  3. Intravenous Vitamin C Administration Decreases Nitric Oxide Serum Level In Severe Burn Injury
  4. The Overview Of Macrophage, Mast Cell, And Lymphocyte Activity In The Efficacy Distinction Of Pain Reduction For Dry And Wet Cupping Therapies
  5. Effectiveness Of Fosfomycin On Prevention Of Surgical Site Infection Of Closed Brain Injury Patients After Craniotomy In Emergency Unit Dr. Soetomo Hospital
  6. Soot Particulate Matter Exposure Increases Interleukin 6 Levels In The Mechanism Of Cardiovascular Disorders
  7. Electric Shock Increases Vcam And Mcp In Mice Endothelial Blood Vessel
  8. Magnesium And Potassium Parenteral Supplementation Does Not Produce Significant Effect On Magnesium And Potassium Serum Level Of Cervical Cancer Patients Receiving Cisplatin Chemotherapy
  9. Effect Of G-csf On Anc Level In All (acute Lymphoblastic Leukemia) Patient With Neutropenia And Febrile Neutropenia During Chemotherapy
  10. Comparative Effectiveness Of Paracetamol And Metamizol As Antipyretics In Patients With Moderate And Severe Brain Injury In Dr. Soetomo Hospital, Surabaya
  11. Analysis Of Complicated Factors Affecting Therapy Effectiveness In Urinary Tract Infections
  12. In Infant With Acute Diarrhea, Nutritional Status Has Correlation With Dehydration Degree, But Not With Mother’s Education And Breastfeeding
  13. The Use Of Antibiotics In Patients With Urinary Tract Infection

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