UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 48 / No. 4 / Published : 2012-10

Order : 2, and page :150 - 155

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Original Article :

Oral and topical aloe vera extract administration in diabetic mice (mus musculus) wound healing process

Author :

  1. Pratitis Amalia*1
  2. Yan Efrata Sembiring*2
  3. Yuani Setiawati*3
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

Aloe vera has been used for medicinal purposes in some cultures for thousands years. In some of the studies that have been conducted in experimental animals, administration of Aloe vera has been proven effective to accelerate wound healing, both in diabetic and non-diabetic wound. In this experiment, the researcher wanted to compare the effect of Aloe vera extract orally and topically to diabetic wounds. The type method of this research is experimental research, which use male mice as experiment animal that had been induced diabetes using STZ. They were divided into 3 groups (control, oral, topical). Then the mice were wounded with a 1x1 cm incision on the back. Aloe vera extract is conducted in oral and topical group. Observations were made on days 3 and 6, mice were euthanized from each group and area around the wound were excised in order to make histopathology preparations. Each preparation was observed under microscope by observing the number of macrophages and fibroblasts in the area of injury as much as 6 field of view with 400x magnification. The results are presented in descriptive observation. On day 3 observation, the number of macrophages and fibroblasts in the topical group more than the oral group. But on the 6th day, the histopathology preparations of the oral group showed no macrophage and fibroblast cell infiltration, so it is difficult for researcher to compare the effects of Aloe vera extract on oral and topical group on day 6. In conclusions, application of Aloe vera extract topically have a better effects on the number of macrophages and fibroblasts infiltrate than oral application in the inflammatory phase of the diabetic wound healing process. (FMI 2012;48:150-155)

Keyword :

Aloe vera extract, diabetic wounds, wound healing, oral, topical,


References :

Atiba A, Ueno H, Uzuka Y,(2011) The effect of Aloe vera oral administration on cutaneous wound healing in type 2 diabetic rats - : J Vet Med Sci

Chithra P, Sajithlal GB, Chandrakasan G,(1998) Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats - : Mol Cell Biochem





Archive Article

Cover Media Content

Volume : 48 / No. : 4 / Pub. : 2012-10
  1. Antibacterial Activity Of Belimbing Wuluh (averrhoa Bilimbi Linn) Extract On Salmonella Typhi Growth
  2. Oral And Topical Aloe Vera Extract Administration In Diabetic Mice (mus Musculus) Wound Healing Process
  3. Effect Of Combined 500 Mg Vitamin C And 200 Iu Vitamin E On Plasma Malondialdehyde Level After Physical Exercise In Diving Athletes
  4. Antibacterial Activity Of Kunyit (curcuma Longa) Leaves Extract On Staphylococcus Aureus Examined Using Dilution Method
  5. Antibacterial Effect Of Strawberry (fragaria X Ananassa) Extract On Pathogenic Serotype 1-11 Escherichia Coli Revealed Using Dilution Method
  6. Guava (psidium Guajava L.) Juice Is Effective In Lowering Blood Glucose Level In Mice (mus Musculus)
  7. Clinical Profile Of Children With Steroid-sensitive Idiopathic Nephrotic Syndrome Relapsing In The First Year At Dr. Soetomo Hospital, Surabaya
  8. The Effects Of Soot Particulate Exposure On Tnf-α Expression In The Mechanism Of Cardiovascular Disorders
  9. Atomoxetine Therapy Effectiveness In Children With Adhd At Day Care, Dr. Soetomo Hospital, Surabaya
  10. Sweet Star Fruit Reduces Blood Pressure In Normotensive Subjects

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