UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 42 / No. 3 / Published : 2006-07

Order : 2, and page :142 - 146

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Original Article :

Pattern of transforming growth factor-ß1 (tgf-ß1) level in bph and non-bph patients

Author :

  1. Endang Retnowati*1
  2. Siswanto Darmadi*2
  3. Magdalena Tobing*3
  4. Soetojo*4
  1. Department of Clinical Pathology, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya
  2. Department of Clinical Pathology, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya
  3. Department of Clinical Pathology, Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya
  4. Department of Urology Airlangga University School of Medicine Dr. Soetomo Teaching Hospital, Surabaya

Abstract :

The etiology and pathogenesis of Benign Prostatic Hyperplasia (BPH) remains unclearly defined, and one of this unclarity is the reduction of Transforming Growth Factor-β1 (TGF-β1) level. The aim of this study was to disclose the role of TGF-β1 in the pathogenesis of BPH. The study on plasma TGF-β1 level pattern was carried out to BPH patients (group 1), non-BPH patients of more than 50 years of age (group 2), and non-BPH patients of less than 50 years of age (group 3). The samples in these groups comprised 18, 17, and 13 individuals respectively, and the TGF-β1 level in respective groups were ranging between 3.4 to 31.52 (14.72 + 8.07) ng/ml, 1 to 65.3 (25.42 +17.97) ng/ml and 4.7 to 69.6 (23.76 + 19.56) ng/ml. The mean of plasma TGF-β1 level in BPH patients was lower that that of non-BPH group irrespective of their age. There was difference in plasma TGF-β1 between that in group 1 and 2 after being tested with independent sample t 2 test (p = 0.035), probably due to the role of plasma TGF-β1 in BPH pathogenesis directly and indirectly. It is suggested to undertake further studies using tissue sample from BPH patient and normal prostate tissue to prove that TGF-β1 has an important role in BPH pathogenesis.

Keyword :

Transforming Growth Factor-β1 (TGF-β1), Benign Prostatic Hyperplasia (BPH),


References :

AJ Bretland,(2001) Role of endogenous transforming growth factor b (TGF b)-1 in prostatic stromal cells no info : Prostate

SV Raid,(2001) Role of endogenous transforming growth factor b (TGF b)-1 in prostatic stromal cells no info : Prostate

CR Chapple,(2001) Role of endogenous transforming growth factor b (TGF b)-1 in prostatic stromal cells no info : Prostate

CL Eaton,(2001) Role of endogenous transforming growth factor b (TGF b)-1 in prostatic stromal cells no info : Prostate

JJMCH de La Rosette,(2001) EAU Guidelines on Benign Prostatic Hyperplasia (BPH) no info : Eur Urol

RI Elliott,(2005) Role of Transforming Growth Factor Beta in human cancer no info : J Clin Oncol

GC Blobe,(2005) Role of Transforming Growth Factor Beta in human cancer no info : J Clin Oncol

RS Kirby,(1997) Benign Prostatic Hyperplasia Scotland : Mosby

TJ Christmas,(1997) Benign Prostatic Hyperplasia Scotland : Mosby

C Lee,(2001) Regulation of prostate grow



Archive Article

Cover Media Content

Volume : 42 / No. : 3 / Pub. : 2006-07
  1. Chromosome Analysis From Lymphocyte Culture In Sexual Ambiguity Patient
  2. Pattern Of Transforming Growth Factor-ß1 (tgf-ß1) Level In Bph And Non-bph Patients
  3. Changes In The Level Of Acth, Cortisol And Lymphocyte T Count After Establishing Diagnosis Of Hiv And Aids
  4. The Effect Of Aerobic Exercise On The Erythrocyte Osmotic Fragility Of The Wistar White Rats
  5. The Equation Analysis Of Linear Pharmacokinetics Models By Akaike's Information Criterion (aic) Of Diminazene Aceturate In Blood Plasma
  6. Comparison Between 0.1% Diclofenac Natrium And 0.1% Dexamethasone Eyedrops In Reducing Cataract Postoperative Inflammation
  7. The Pharmacokinetics Of Lamivudine In Healthy Rabbit Treated With Cimetidine
  8. Validity And Reliability Of Radar Questionnaire For Patients With Rheumatoid Arthritis
  9. Height Measurement Based On Sternal Bone Length In Adults
  10. Antimicrobial Resistance And Antibiotic Use In Low-income And Developing Countries
  11. Urethral Stricture In Female
  12. Review Article And Clinical Experience: Recent Advances In Diabetes Mellitus: 2002-2005. Selected Clinical Aspects, Clinical Experiences, And Possible Applications

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