UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 40 / No. 3 / Published : 2004-07

Order : 8, and page :103 - 107

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Original Article :

Pharmacodynamic identification of antiseizure effect of ligustrosid glycoside (a cns active substance) isolated from fraxinus griffithii clarke on mice

Author :

  1. Achmad Basori*1
  1. Department of Pharmacology Airlangga University School of Medicine

Abstract :

A study was conducted to prove whether Ligustrosid (A CNS Active substance) isolated from bark of Fraxinus griffithii Clarke has antiseizure effects. Antiseizure test showed that Ligustrosid increased seizure treshold on epileptic animals injected by CD 90 Metrazol i.p. (ED 50 Anti Met : 278.54 mg/kg BW), and prevented seizure spread (ED 50 Anti M.E.S : 431.61 mg/kg BW). Furthermore, these experiment reported that Ligustrosid decreased Metrazol lethality test on animals. The capability of Ligustrosid to increase the seizure treshold against Anti Metrazol test meant that Ligustrosid clinically would be active against absence seizures and myoclonic seizures. It is strongly supposed that Ligustrosid may has antiseizure effects by increasing GABA- facilitated inhibition in CNS through interaction with Benzodiazepine receptor of GABA-BZD-BARB/PICRO-CL receptor complexes. The capability of Ligustrosid to prevent seizure spread against Anti M.E.S test meant that Ligustrosid clinically would be active against generalized tonic clonic seizures and partial seizures. It is strongly supposed that ligustrosid may has antiseizure effects by stabilizing membrane through interaction with Sodium channel receptors. Further research will be needed to explore antiseizure mechanisms of Ligustrosid

Keyword :

ligustrosid , Anti MES, Anti Met, antiseizure effect,


References :

Porter RJ,(1993) Antiepileptic Drugs Future Development, In: New Antiepileptic Drug Development, Preclinical and Clinical Aspects, edited by French, JA, Dichter MA, dan Leppik IE Netherlands : Elsevier

Porter RJ and Meldrum BS,(2001) Antiseizure Drugs, In: Basic and Clinical Pharmacology, edited by BG Katzung, 8th edition NY : Lange Medical Books





Archive Article

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Volume : 40 / No. : 3 / Pub. : 2004-07
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  2. Opinion: International Ethical Guidelines For Biomedical Research Involving Human Subjects
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  7. Preserved Amniotic Membrane Graft After Bare Sclera Technique With Mitomycin C For Pterygium Surgery
  8. Pharmacodynamic Identification Of Antiseizure Effect Of Ligustrosid Glycoside (a Cns Active Substance) Isolated From Fraxinus Griffithii Clarke On Mice
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