UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 4 / Published : 2008-10

Order : 3, and page :233 - 241

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Original Article :

Potential value of c-reactive protein as inflammation marker and il-1β, tnf- as pro-inflammatory cytokine on disease activity of rheumatoid arthritis

Author :

  1. FM Judajana*1
  1. Department of Clinical Pathology, University of Airlangga School of Medicine Dr Soetomo Teaching Hospital, Surabaya

Abstract :

A study on the role of C reactive protein as inflammatory marker and IL-1b, TNF-a as pro inflammatory cytokine on disease severity of rheumatoid arthritis, was performed 40 patients comprising 33 females and 7 males. All patients had received treatment with single or combined therapy using corticosteroid, NSAID or DMARDs. The patients were group into 4 categories according to the degree of disease severity with Disease activity score (DAS 28) methods. 14 Patients showed severe disease activity (DAS > 511) 16 patients showed moderate disease activity (3.2 < DAS <5.1). It was found that many patients with severe or moderate disease activity showed IL-1b concentration, TNF and CRP concentrations had a significant correlation with the assessment of rheumatoid arthritis disease activity on 28 joint (DAS 28). This study did not show a significant correlation between IL-1b concentration and CRP concentration (r=+0.005, p= 0.981), but have positive correlation between IL-1b and DAS 28 (r = +0.300, p = 0.048) as well as between CRP concentration and DAS 28 (r=+0.074, p=0.704). The correlation between TNF-a and CRP did not showed significant, because the CRP concentration is influenced by genetic polymorphism of CRP gene, IL-1b gene, short half life of CRP and the usage of drugs (NSAID, corticosteroid, DMARDs) between CRP concentration and DAS 28 (r=+0.074, p=0.704). The principle finding of this study concluded that there was a significant association between pro-inflammatory cytokine (IL-1b and TNF-a) and disease severity of RA (DAS 28). It was shown that the plasma level IL-1b has significant correlation with severe as well as moderate degree of disease activity, while the plasma levels TNF-a has significant correlation with severe disease activity as based on measurement by DAS28. The data found in this study indicates that screening of C reactive protein and the combined use of IL-1b and TNF-a could be considered as a powerful approach to identify subjects at risk for rheumatoid arthritis, and need a large scale of population study which may be used as the basis for the design of new intervention strategies, especially in order to improve the degree of disease severity.

Keyword :

Rheumatoid arthritis, C reactive protein, IL-1β, TNF-α , DAS 28,


References :

Abbas, AK, Lichtman, AH, Pillai, S,(2004) The major histocompatibility complex, in Cellular and Molecular Immunology, 5th edn Philadelphia : Saunders Elsevier Publisher

Abbas, AK,(2005) Disease of immunity, in V Kumar, AK Abbas, N Fausto (eds), Pathologic Basis of Disease, 7 th Ed. Philadelphia : Elsevier Saunders Publisher

Albany, S and Carson, DA,(1997) Etiology and pathogenesis of rheumatoid arthritis, in WJ Koopman (ed), Arthritis and Allied Conditions Baltimore : Williams and Wilkins





Archive Article

Cover Media Content

Volume : 44 / No. : 4 / Pub. : 2008-10
  1. Genetic Variation Of G6pd And Adaptive Phenomena In Malarial Infection
  2. Molecular Analysis Of The Coding Sequence Of Mage-1 Gene From Hepatocelular Carcinoma Patient And Testis
  3. Potential Value Of C-reactive Protein As Inflammation Marker And Il-1β, Tnf- As Pro-inflammatory Cytokine On Disease Activity Of Rheumatoid Arthritis
  4. Cell Surface Her2/neu Oncoprotein Expression In Breast Ductal Carcinoma
  5. Difference In The Productivity Of B-lymphocyte Isolated From Lymph Nodes And That Isolated From Mice Spleen In The Production Of Toxocara Cati Monoclonal Antibody Using Hybridoma Technology
  6. Exploration In The Use Of Medicinal Plant Acanthus Ilicifolius L In The Treatment Of Endothelial Dysfunction
  7. Detection Of M. Tuberculosis And Drug Sensitivity Test From Sputum Culture Of Pulmonary Tuberculosis Patients In Dr Soetomo General Hospital Between 2003-2004
  8. The Pharmacokenetics Of Levofloxacin In Healthy Rabbit Treated With Antacid
  9. Potency Of Lactobacillus Reuteri On Reduced Inflammation In Septic Encephalopathy
  10. Pharmacokinetic Parameters Determination Of A Single 500-mg Oral Dose Of Levofloxacin In Healthy Subjects By Using Blood Data
  11. Encephalopathy And Neuroendocrine Disorder In Septic Shock
  12. Osteoarthritic Pain Treatment With Electroacupuncture
  13. Review Article And Clinical Experience: Astaxanthin – Oxidative Stress – Diabetes Mellitus From Basics To Clinics And From General To Specific

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