UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 44 / No. 2 / Published : 2008-04

Order : 1, and page :67 - 70

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Original Article :

Tgf-β1 as the trigger of pulp fibroblast proliferation

Author :

  1. Sri Kunarti*1
  1. Department of Conservative Dentistry, Airlangga University School of Dentistry, Jl. Prof Dr Moestopo 47, Surabaya

Abstract :

Mechanical pulp exposure by a rotary cutting instrument or a hand cutting instrument often occurs in deep caries. The application of a protective dressing can protect the pulp from additional injury by facilitating healing and repair. Pulp capping has been suggested as one treatment of choice after pulp exposure to maintain pulp vitality. TGF-1 is a growth factor that has important role in wound healing. The application of exogenous TGF-1 as direct pulp capping treatment to induce endogenous TGF-1 is for reparative dentinogenesis. Samples were taken from orthodontic patients indicated for premolar extraction, between ages 10 – 20 years. The samples were divided into 2 treatment groups: group I was treated by TGF-1 and group II as a positive control was treated by Ca(OH)2. A class V cavity preparation was created in the buccal aspect 1 mm above gingival margin until pulp exposure. The sterile absorbable collagen membrane was used as inert carrier of 20ng/ml TGF-1 and was soaked with 5 ul. All groups were covered by a teflon pledge to separate pulp capping agent from Glass ionomer cement type II as a restoration. Teeth were extracted in 7, 14 and 21 day after treatment. All samples were examined histopathologically. Data analysis used one way Anova and student t test for parametric data. The exogenous TGF-1 increased stellate fibroblast (means TGF-1 > Ca(OH)2). In conclusion, the exogenous TGF-1 increased stellate fibroblast development.

Keyword :

stellate fibroblast, TGF-1, calcium hydroxide, pulp capping,


References :

Alberts, B, Bray, D, Lewis, J, Raff, M, Roberts, K, Watson, JD,(1994) Cell signaling, in Molecular Biology of the Cell, 3rd edn New York & London : Garland Publishing Inc.

Gunawan, A & Amindariati, S,(2003) Histologi I, 1st edn Surabaya : Department of Anatomy and Histology, Airlangga University School of Medicine





Archive Article

Cover Media Content

Volume : 44 / No. : 2 / Pub. : 2008-04
  1. Tgf-β1 As The Trigger Of Pulp Fibroblast Proliferation
  2. Difference In Cyclooxygenase-2 (cox-2) Expression Between Low And High Grade Papillary Carcinoma In Human Bladder Cancer
  3. Detection Of Cytokeratin 19 Mrna In Blood As An Early Marker Of Micrometastatic Tumor Cells Of Nasopharyngeal Carcinoma Patients In Surabaya
  4. Pcr Technique Detection Of Chlamydia Trachomatis Dna Band Using Silver Nitrate Staining
  5. Change Of Cd4 Count, Hsp70 And Anti-hsp70 Levels In Hiv Patients
  6. Hiv/aids Prevalence In Surabaya, Indonesia
  7. Treatment Response And Acute Toxicity Evaluation Of 70 Gray Radiation In Nasopharyngeal Carcinoma Patients In Dr Soetomo Hospital, Surabaya
  8. Pharmacodynamic Effects Of Ligustroside Glycoside (a Cns Active Substance) Isolated From Fraxinus Graffithii Clarke Against Chemically Induced Seizures On Mice
  9. Management Of Acute Glomerulonephritis In A Child With Ischemic Stroke And Hypertensive Crisis
  10. Efficacy Of Orlistat Plus Diet Compared To Diet Alone In Reducing Body Weight And Body Mass Index
  11. Review Article: Pathogenesis Of Repeated Abortion In Polycystic Ovarian Syndrome (pcos)
  12. Review Article: Protein Calorie Malnutrition And Immune Response In Children
  13. Review Article And Clinical Experience: Varenicline (champix®) : A Breakthrough For Smoking Cessation Treatment (an α4ß2 Nicotinic Acethylcholine Receptor Partial Agonist)

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