UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 49 / No. 4 / Published : 2013-10

Order : 8, and page :244 - 251

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Original Article :

The prevalence of extended spectrum beta-lactamase (esbl) in third generation cephalosporin usage among sepsis patients in the department of internal medicine rsud dr. soetomo surabaya

Author :

  1. Bramantono*1
  2. Purwati*2
  3. Hamidah*3
  1. Dosen Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran
  3. Dosen Fakultas Kedokteran

Abstract :

The incidence of sepsis and death caused by sepsis increases each year. Beta-lactam antibiotics is widely used to treat many types ofinfections because of its minimum side-effects. As a result of the widespread use of broad spectrum cephalosporin, an ExtendedSpectrum ß-lactamase (ESBL) enzyme produced by K. ozaenae has developed. Since then, other types of ESBL have been found andspread around the world relatively fast. The prevalence of infection caused by ESBL-producing bacteria varies in each country. InIndonesia, the incidence of ESBL in Enterobacteriaceae is still not widely known. This research aims to investigate the prevalence ofESBL in third generation cephalosporin usage among sepsis patients in The Department of Internal Medicine of RSUD Dr. SoetomoSurabaya. This crossectional study is conducted in The Department of Internal Medicine RSUD Dr. Soetomo Surabaya betweenNovember 1st 2011 and February 29th 2012. Demographic characteristics of patients and the basic diagnose were obtained from themedical record. Specimen were collected to examine bacterial culture and antibiotic sensitivity testing, complete blood laboratoryexamination, complete urine examinationm liver function tests and kidney function test. Data were analyzed using SPSS 18.0. Of the30 sepsis patients, 2 were ESBL-positive (6.66%). ESBL-positive incidence were in the age group 41-50 and 61-70 years old, allmale. Pneumonia and hepatobilliary disease were the underlying disease. ESBL-positive culture were obtained in blood and sputumisolates. ESBL-producing bacteria were Klebsiella pneumoniae dan Enterobacter coxacie with the most sensitivity towardslevofloxacin, imipenem and meropenem.(FMI 2013;49:244-251)

Keyword :

Extended Spectrum Beta-Lactamase (ESBL), third generation cephalosporin, sepsis, RSUD Dr Soetomo,


References :

Al-Jasser AM,(2006) Extended-spectrum betalactamases (ESBLs): a global problem - : Kuwait Medical Journal

Almog Y,(2003) Statins, inflammation, and sepsis: hypothesis - : Chest





Archive Article

Cover Media Content

Volume : 49 / No. : 4 / Pub. : 2013-10
  1. Relationship Between N-terminal Pro-brain Natriuretic Peptide (nt-probnp) Level And Protein St2 Level In Acute Coronary Syndrome Patient
  2. The Effect Of Lime Peel Extract (citrus Aurantifolia) To Total Blood Cholesterol Levels Of Mice (mus Musculus) That Given The High Cholesterol Diet
  3. Monitoring Of Potassium Level On The Heart Failure Patients Using Captopril And Furosemide
  4. Effect Of Red Yeast Rice (monascus Purpureus) Extract To The Trombopoietin Level In Dengue Infected Patients
  5. Amaranthus Tricolor Linn Preserves The Thickness Of Seminiferous Tubules In Mice (mus Musculus) Induced By Lead Acetate
  6. Effect Of Low Molecular Weight Topical Hyaluronate On White Rat Superficial Wounds Epithelization Treated With Freeze-dried Amnion Membrane
  7. Profile Of Chest And Abdomen Ultrasound On Patients With Dengue Virus Infection In Dr. Soetomo Hospital Surabaya Between February-april 2012
  8. The Prevalence Of Extended Spectrum Beta-lactamase (esbl) In Third Generation Cephalosporin Usage Among Sepsis Patients In The Department Of Internal Medicine Rsud Dr. Soetomo Surabaya
  9. Case Report: Management Of Peptic Ulcer Infection Due To Helicobacter Pylori Infection And Abscess Liver Bowel Perforation
  10. Difference Of Pain Intensity In Tension Type Headache Patients Focusing On The Personality
  11. Hearing Disorder In Multidrug-resistant Tuberculosispatients Atthe Outpatients Unit, Pulmonary Department, Dr. Soetomo Hospital Surabaya
  12. The Difference Of Heart Rate Recovery Among Obese Subjects With And Without Metabolic Syndrome
  13. Dysfunction Of Cochlear And Retrocochlear With Tinnitus In Normal Hearing

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