UNIVERSITAS AIRLANGGA



Detail Article

Folia Medica Indonesiana

ISSN 0303-7932

Vol. 43 / No. 3 / Published : 2007-07

Order : 4, and page :148 - 152

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Original Article :

Use of haematological and immunological biomarker as indicator of pb intoxication

Author :

  1. Tri Martiana*1
  1. Department of Occupational Safety and HealthAirlangga University School of Public HealthSurabaya

Abstract :

Transportation and industrial activities give high contribution to Pb exposure. The level of Pb in the air increases to 1.6-42 µg/m3 (WHO standard 0.001µg/m3) and in water reaches 120 µg/dl (WHO < 60 µg/dl). There are some researchers who examined the impact of Pb to health, but the results had insignificant impact. The objective of the study was to reveal the impact of Pb exposure to haemotological and immunological system. The research was done by the metaanalysis method from similar researches. This article metaanalyses the research that used haematological and immunological system variables to Pb exposed objects. Variables in the haematological system which can be used as biomarker are the increase young reticulocyte, basophilic stippling, howel jolly bodies (normally not occurred), thrombocytosis, and blood zinc protophorphyrin > 1.3 µmol/l. Biomarker variable in the immunological system was the change of Th1/Th2 balance, in which Th1 showed an increase. In conclusion, haematological and immunological biomarker can be used as the indicator of Pb exposure. Further research is suggested in order to reveal the more specific and sensitive variables.

Keyword :

Plumbum (Pb) exposure, haematologic indicator, immunologic indicator,


References :

JL Anetor,(2002) Observations on the haemapoitic system in tropical lead poisoning no info : Nigerian Journal of Physiological Science

OO Babalola,(2002) Observations on the haemapoitic system in tropical lead poisoning no info : Nigerian Journal of Physiological Science

FAA Adeniye,(2002) Observations on the haemapoitic system in tropical lead poisoning no info : Nigerian Journal of Physiological Science

TS Akingbola,(2002) Observations on the haemapoitic system in tropical lead poisoning no info : Nigerian Journal of Physiological Science

Baratawidjaja,(1996) Imunologi Dasar Jakarta : Fakultas Kedokteran Universitas Indonesia

R Beliles,(1996) Lead, sources, use and industrial exposures New York : Ohn Wiley & Sons.Inc

TL Bunn,(2001) Exposure to lead during critical windows of embryonic development differential immunotoxic outcome based on stage of exposure and gender no info : Toxicol Sci

CDC,(2006) Lead Poisoning Associated with Ayurvedic



Archive Article

Cover Media Content

Volume : 43 / No. : 3 / Pub. : 2007-09
  1. A3243g Mitochondrial Dna Mutation Does Not Play An Important Role Among Dm Population In Indonesia
  2. Effect Of Curcumin On The Levels Of Total Cholesterol, Ldlcholesterol, The Amount Of F2-isoprostan And Foam Cell In Aortic Wall Of Rats With Atherogenic Diet
  3. Increase Of Immunoglobulin A Titer In Mice Intestinal Mucosa After Immunization With Toxoplasma Gondii Soluble Protein With And Without Intranasal Cholera Toxin Adjuvant
  4. Use Of Haematological And Immunological Biomarker As Indicator Of Pb Intoxication
  5. Correlation Between Birthweight And Bodyweight Increase Of Pregnant Women With Normal Body Mass
  6. Analysis Of The Risk Factors Of Pulmonary Edema In Preeclampsiaeclampsia In Dr Soetomo Hospital, Surabaya
  7. The Role Of Laparoscopy Surgery In Infertility
  8. Influence Of Lbw Formula Feeding On The Growth Of Low Birth Weight Infant
  9. Diagnosis Of Upper Urinary Tract Infection Using Streptavidin Biotin Test In Urine Sediment. A New Approach Using Immunohistochemical Test For Determining The Site Of Urinary Tract Infection
  10. Detection Of Dengue Virus Antigen In Monocytes To Support The Diagnosis Of Dengue Hemorrhagic Fever
  11. Drug Utilization Profile In Hiv/aids Patients. Study At Dr Soetomo Teaching Hospital Surabaya

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