UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 2 / No. 2 / Published : 2015-12

Order : 1, and page :34 - 40

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Original Article :

Aktivitas antivirus influenza dari ekstrak metanol buah momordica charantia

Author :

  1. Neny Purwitasari*1
  2. Herra Studiawan*2
  3. Kadek Rahmawati*3
  1. Dosen Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Avian Influenza Research Center, Universitas Airlangga

Abstract :

The outbreak of influenza A (H1N1) viruses has raised a global concern on the future risk of a pandemic. Oseltamivir, the current influenza drug, could not meet the demand if there is a major outbreak. Thus, there is a need to find alternative treatment for influenza A. Our molecular docking work on influenza inhibition activity has led to the selection of plant to be studied, Momordica charantia.  The objectives of this study were to determine the antiviral activity of  Momordica charantia fruits against H1N1 influenza virus inoculated in 11-days embryonated chicken eggs. The antiviral activity was performed in hemaglutination assay using chicken red blood cells. This is a method for titering influenza viruses based on their ability to attach to molecules present on the surface of red blood cells.  Result showed that there is no toxicity detected on the chicken embryos after treated with 1000µg/ml the extract for 72 hours. The extract inhibits 75.5% of the H1N1 hemaglutinin titer. In conclusion, the methanolic extract of Momordica charantia fruits has a potential to be developed as antiinfluenza.

Keyword :

Influenza A, H1N1, Momordica charantia,


References :

Krisnawan AH,(2011) Aktivitas antivirus hasil fermentasi Streptomyces spp. Terhadap virus influenza pandemi H1N1-2009 Skripsi : Fakultas Farmasi Universitas Airlangga

Bawa IGAG,(2009) Isolasi dan identifikasi golongan senyawa toksik dari daging buah pare (Momordica charantia L.) 3 (2): 117-124 : Jurnal Kimia

Dharmayanti NLPI, Hewajuli DA, Ratnawati AK, Indriani R, Darminto,(2010) Karakter genetik protein membran virus avian influenza subtipe H5N1 15 (3): 231-239 : JITV

Untari T, Widyarini S, Wibowo MH,(2012) Aktivitas antiviral minyak atsiri jahe merah terhadap virus flu burung Vol 13, No. 3: 309-312 : Jurnal Veteriner

Radji M,(2006) Avian influenza A (H5N1): patogenesis, pencegahan dan penyebaran pada manusia 3:55-65 : Majalah Ilmu Kefarmasian





Archive Article

Cover Media Content

Volume : 2 / No. : 2 / Pub. : 2015-12
  1. Aktivitas Antivirus Influenza Dari Ekstrak Metanol Buah Momordica Charantia
  2. Identifikasi Golongan Senyawa Dan Uji Toksisitas Akut Ekstrak Etanol 95 Persen Daun, Kulit Batang Dan Akar Pulai (alstonia Scholaris (l.) R. Br.) Terhadap Mencit Balb/c
  3. Aktivitas Antibakteri Kombinasi Susu Probiotik Lactobacillus Bulgaricus Dan Streptococcus Thermophilus Terhadap Bakteri Penyebab Diare
  4. Potensi Antimalaria Dan Pemeriksaan Mikroskopik-fitokima Daun Beberapa Tanaman Genus Cassia
  5. Optimasi Campuran Manitol - Pemanis Stevia Sebagai Pemanis Tablet Kunyah Ekstrak Jahe Merah (zingiber Officinale Roscoe Var.rubrum) Dengan Metode Simplex Lattice Design
  6. Efek Apoptosis Ekstrak Etanol Ganggang Hijau (ulva Lactuca) Pada Jantung Tikus Yang Diinduksi Isoproterenol
  7. The Effect Of Anting-anting (acalypha Indica Linn) Extract With Malondialdehyde Levels Of Balb/c Mice Induced Streptozotocin

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