UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Farmasi dan Ilmu Kefarmasian

ISSN

Vol. 1 / No. 1 / Published : 2014-01

Order : 2, and page :6 - 9

Related with : Scholar   Yahoo!   Bing

Original Article :

Uji aktivitas antimalaria ekstrak air daun johar (cassia siamea lamk) terhadap plasmodium berghei secara in vivo

Author :

  1. Ardhistia Raharjo*1
  2. Wiwied Ekasari*2
  3. Achmad Fuad Hafid*3
  1. Mahasiswa Fakultas Farmasi
  2. Dosen Fakultas Farmasi
  3. Dosen Fakultas Farmasi

Abstract :

The water extract of Cassia siamea Lamk. leaf was evaluated for anti malarial activity in vivo, in 4-day suppressive assays against Plasmodium berghei in mice. An in vivo model to examine the antimalarial effect of plant extract is described. Selected mice (20-30 g body weight) were divided into 6 groups, each consist of 6 mice. Each animal was injected with Plasmodium berghei infected RBCs. The assay was done by Peter’s test, mice were treated orally with diluted extract in dose levels of  12.5 mg/kg bw, 25 mg/kg bw, 50 mg/kg bw, 100 mg/kg bw, 200 mg/kg bw for 5 groups. One group served as control. The negative control was treated with 0.5% CMC Na solution. The control positive was treated with a dose of 10, 5, 1, 0.5,0.1, 0.05 mg/kg  kontrol positif digunakan klorokuin difosfst dengan dosis 10 mg/kg BB. body weight Chloroquine diphosphat solution. The concentration of water extract required for 50% suppression (ED50) of Plasmodium berghei in mice was 83.77412 mg/kg bw.

Keyword :

Cassia siamea Lamk., Plasmodium berghei, Antimalarial activity,


References :

Ekasari W, Wahjo D, Yoes PD, and Suhintam P,(2001) In vitro antiplasmodial activity of alkaloid fraction of chloroform extract of Cassia siamea leaves Jakarta : WHO UI

Sjafruddin D, Siregar JE, Asih PBS,(2004) Antimalarial drug resistance in Indonesia: A molecular analysis. Symposium of malaria control in Indonesia, Proceeding Surabaya : TDC Airlangga University

Sutisna P,(2003) Malaria Secara Ringkas dari Pengetahuan Dasar Sampai Terapan Bali : Fakultas Kedokteran Universitas Udayana

Ekasari W, Aty W, Suhintam P,(2002) Daya skinzontosida ekstrak etanol, ekstrak kloroform dan fraksi yang positip alkaloid daun C. siamea pada biakan in vitro P. falciparum Surabaya : Penelitian BBI. Lemlit Unair

Philipson, JD,(1991) Assays for Antimalarial and Amoebicidal Activities London : Academic Press London





Archive Article

Cover Media Content

Volume : 1 / No. : 1 / Pub. : 2014-06
  1. Pemberian Informasi Lama Terapi Dan Konfirmasi Informasi Obat Perlu Ditingkatkan Di Puskesmas
  2. Uji Aktivitas Antimalaria Ekstrak Air Daun Johar (cassia Siamea Lamk) Terhadap Plasmodium Berghei Secara In Vivo
  3. Pelepasan Gentamisin Dari Pelet Bovine-hydroxyapatite-gelatin Sebagai Sistem Penghantaran Obat Dan Pengisi Tulang
  4. Aktivitas Antiviral Batang Eucalyptus Globulus Terhadap Virus Hepatitis C Jfh1a
  5. Sintesis Khalkon Dan Derivatnya Menurut Reaksi Kondensasi Claisen Schmidt Dengan Iradiasi Gelombang Mikro
  6. Penentuan Dosis Asam P-metoksisinamat (apms) Sebagai Antiinflamasi Topikal Dan Studi Penetrasi Apms Melalui Kulit Tikus Dengan Dan Tanpa Stratum Korneum
  7. Studi Kelarutan Dan Disolusi Kompleks Inklusi Ketoprofen-hidroksipropil -siklodekstrin (dibuat Dengan Metode Kopresipitasi)

Information index.php/JIPK/tmp_tumb/JFIK