UNIVERSITAS AIRLANGGA



Detail Article

VetMedika Jurnal Klinik Veteriner

ISSN 2302-6499

Vol. 3 / No. 1 / Published : 2014-07

Order : 3, and page :8 - 11

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Original Article :

Combination of diphenhydramine-ketamine as general anasthesia in rabbit (ornytolagus cuniculus) performs a faster onset and longer duration of action compared to ketamine

Author :

  1. Nicky Putri Santoso*1
  2. Sri Agus Sudjarwo*2
  3. Rudy Sukamto Setiabudi*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

This research was aimed to compare the onset and duration of action between ketamine and combinations of diphenhydramine-ketamine. Twenty adult male rabbits were divided into four groups of treatments and each treatments  consist of five replications. Control group (P0) injected with ketamine 50 mg/kg of body weight. While treatments group (P1), (P2), (P3) were injected with diphenhydramine  1, 2, 4 mg/kg of body weight respectively. After 50 minutes, all groups injected with ketamine 50 mg/kg of body weight. The data were tested with ANOVA (Analysis of Variance) then continued with Duncan’s Multiple Range test (p<0.05). There is a significant difference of onset and duration of action between ketamine and ketamine-diphenhydramine groups. The best data of onset and duration of action were performed by group P2 which combined diphenhydramine 2 mg/kg of body weight with ketamine 50 mg/kg of body weight.

Keyword :

ketamine, diphenhydramine, rabbit, anesthesia, onset of action,


References :

Brodbelt, D.C., J. C. Brearley, and L.J. Young,(2005) Anaesthetic Related Mortality Risksy in Small Animals in the UK. Rome : Proceedings of AVA Spring Meeting, Rimini. Italy. Page 67

Flecknell, P.A. ,(1987) Laboratoty Animal Anaesthesia. San Diego : Academic Press. San Diego. Page: 98-99.

Grint, N. J. and P. J. Murrison,(2008) A Comparison of Ketamine-Midazolam and Ketamine-Medetomidine Combinations for Induction of Anaesthesia in Rabbits. New York : Vet. Anaesth. Analg. 35, 113- 121.

Reiner, P. B.,and A, Kamondi,(1994) Mechanisms of Antihistamine-Induced Sedation in The Human Brain : H1 Receptors Activation Reduces a Background Leakage Potassium Current. New York, USA : Neuroscience 59 (3). 579-88.

I Komang Wiarsa Sardjana dan Diah Kusumawati Gali,(2011) Anestesi veteriner Jilid I. Yogyakarta : Gadjah Mada University Press. Bulaksumur. Yogyakarta. Page: 1-49.





Archive Article

Cover Media Content

Volume : 3 / No. : 1 / Pub. : 2014-07
  1. Radiology Based Detection Of Osteoporosis In Ovariohysterectomized Cat (felis Silvestris Catus)
  2. The Case Of Canine Mammary Gland Tumors In The Veterinary Teaching Hospital Faculty Of Veterinary Medicine Airlangga University Surabaya Period Of 2011 - 2013
  3. Combination Of Diphenhydramine-ketamine As General Anasthesia In Rabbit (ornytolagus Cuniculus) Performs A Faster Onset And Longer Duration Of Action Compared To Ketamine
  4. The Effect Of Green Cincau Leaves Extract (cyclea Barbata L. Miers) For Total Fibroblast And Density Of Collagen On Mice's Skin
  5. The Effects Of Cikal Tulang (cissus Quadrangularis) Extract For Osteoporosis Prevention In Ovariectomyzed Rats (rattus Norvegicus) Based On Histopathology Structure Of Mandible Bone
  6. Incidence Of Urolithiasis In The Dogs At Animal Health Care Center In Surabaya, Period 2012-2013

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