UNIVERSITAS AIRLANGGA



Detail Article

VetMedika Jurnal Klinik Veteriner

ISSN 2302-6499

Vol. 6 / No. 2 / Published : 2018-01

Order : 2, and page :5 - 9

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Original Article :

Influence of onion (allium cepa l) ethanol extract on white rats islet langerhans (rattus norvegicus) induced with alloxan

Author :

  1. Ananda Bagus Setiawan*1
  2. Retno Bijanti*2
  3. Thomas V Widiyatno*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The purpose of this research was to know the influence of onion (Allium cepa l.) ethanol extract on white rats islet of Langerhans (rattus norvegicus) with diabetes mellitus. This study was experimental study, using male rats with 150-200 gram weight induced hyperglicemic with alloxan 120 mg/kgBW (IP). Samples consist of twenty rats were divided into five groups, negative control group (K-) was not induced by alloxan, which treatment by giving CMC Na 0,5%, positive control group (K+) was induced by alloxan without onion ethanol extract, group 1 (P1) was induced by alloxan and gave onion ethanol extract 200 mg/kgBW, group 2 (P2) was induced by alloxan and gave onion ethanol extract 400 mg/kgBW, group 3 (P3) was induced by alloxan and gave onion ethanol extract 800 mg/kgBW daily for 14 days period. The tissue is stained with Hematoxylin-Eosin for morphological studies and analysis of the average islet of Langerhans island. The data have been described in the table form, analyzed with One Way Anova for the normality of the data, furthermore analyzed with Duncan test. The results of this research showed that addingethanol extract of onion (Allium cepa L.) with the dose 400 mg/kgBWgroup 2 (P2) was significantly higher (p< 0,05) than the group 1 (P1) 200 mg/kgBW, group 3 800 mg/kgBW, and ppsoitive control group K(+)

Keyword :

allium cepa l., alloxan, hypergylcemic, islet of langerhans, rats,


References :

Erwin., Etrinawati., Muttaqien., T.W, Pangestiningsih., dan S, Widyarini.,(2013) Ekspresi Insulin pada Pankreas Mencit (Mus musculus) yang Diinduksi dengan Streptozotocin Berulang. 7(2): 97-100 : Jurnal Kedokteran Hewan

Nugroho, B. A. dan Purwaningsih, E.,(2004) Pengaruh Diet Ekstrak Rumput Laut (Eucheuma sp.) Terhadap Kadar Glukosa Darah Tikus Putih (Rattus Norvegicus) Hiperglikemik. Vol.39 No. 3, 154 – 60 : Media Medika Indonesia

Putri, N.H.K, dan M.P. Isfandiari.,(2013) Hubungan Empat Pilar Pengendalian DM Tipe 2 Dengan Berata Kadar Gulah Darah. - : Fakultas Kesehatan Masyarakat Universitas Airlangga. Surabaya.

Upadhyay R.K.,(2016) Neutraceutical, phamaceutical and therapeutic uses of Allium cepa. - : Departement of Zoology. D D U Gorakhpur University, Gorakhpur, Uttar Pradesh, India.





Archive Article

Cover Media Content

Volume : 6 / No. : 2 / Pub. : 2018-01
  1. The Effect Of Kersen Leaf (muntingia Calabura L.) Extract To Blood Glucose Level Of Rats (rattus Norvegicus) Model Diabetes Melltius Type 1 Induced By Alloxan
  2. Influence Of Onion (allium Cepa L) Ethanol Extract On White Rats Islet Langerhans (rattus Norvegicus) Induced With Alloxan
  3. The Effect Of Pomegranate Fruit Extract Standardized 40% Ellagic Acid Topically To The Collagen Density On Incision Wound In Albino Rat (rattus Norvegicus)

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