UNIVERSITAS AIRLANGGA



Detail Article

VetMedika Jurnal Klinik Veteriner

ISSN 2302-6499

Vol. 6 / No. 2 / Published : 2018-01

Order : 1, and page :1 - 4

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Original Article :

The effect of kersen leaf (muntingia calabura l.) extract to blood glucose level of rats (rattus norvegicus) model diabetes melltius type 1 induced by alloxan

Author :

  1. Nur Lailatul F.N.*1
  2. Dewa Ketut Meles*2
  3. Kusnoto*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The experiment was conducted to determine antidiabetic effect of repeated oral administration of kersen leaf extract (Muntingia calabura L.) in alloxan induced diabetic rats (Rattus norvegicus). Alloxan was injected intraperitoneally at 120 mg/kgBW(single dose). A total of thirty male rates aged two until three months old were used this study. The rats were divided into six groups. 1) negative control group (K-) was treated by CMC Na 1 %, 2) positive control group (K+) had been inducted by alloxan and treated by metformin 12,6 mg/200gBW, 3) group (P0) had been inducted by alloxan and treated by CMC-Na%, 4) group (P1) had been inducted by alloxan and treated by extract of Muntingia calabura L. 250 mg/KgBW, 5) group (P2) had been inducted by alloxan and treated by extract of Muntingia calabura L. 500 mg/KgBW, 6) group (P3) had been inducted by alloxan and treated by extract of Muntingia calabura L. 1000 mg/KgBW. Blood specimen were collected from coccygealis vein, then analyzed using on call® glucometer. The result of this study showed that Muntingia calabura L. extract has a high antidiabetic potential that decreases the blood glucose level during 14 days post treatment. Kersen leaf extract consists of flavonoid, tannin and saponin that are able to reduce the blood glucose level. After 14 days post treatment, the average result of blood glucose level with 250 mg/kgBW (P1) dosage didn’t decrease blood glucose level to the normal level and 1000 mg/KgBW (P3) dosage was proven to be the most effective dosage among all the grups experimented.

Keyword :

Muntingia calabura L., alloxan, antidiabetic, blood glucose, rats,


References :

Kumari, M. and S. Jain.,(2012) Tannins : An Antinutrient with Positive Effect to Manage Diabetes. Vol. 1 (12), pp. 70-71 : Researh Journal of Recent Science

Nugroho, B. A. dan E. Purwaningsih.,(2004) Pengaruh Diet Ekstrak Rumput Laut (Eucheuma sp.) Terhadap Kadar Glukosa Darah Tikus Putih (Rattus Norvegicus) Hiperglikemik. Vol.39 No. 3, 154 – 60 : Media Medika Indonesia

Prawita, E.C.,(2017) Pengaruh Pemberian Ekstrak Ethanol Bawang Bombang (Allium ceppa L. ) terhadap Kadar Glukosa Darah Tikus Putih Rattus norvegicus yang Diinduksi Aloksan. - : [Skripsi] Fakultas Kedokteran Hewan Universitas Airlangga

Utama, R.P.,(2011) Uji Aktivitas Anti Diabetes Fraksi Etil Asetat daun Kersen (Muntingia Calabura L.) pada Mencit Diabetes. - : [Skripi] Fakultas Farmasi. Universitas Negeri Jember.





Archive Article

Cover Media Content

Volume : 6 / No. : 2 / Pub. : 2018-01
  1. The Effect Of Kersen Leaf (muntingia Calabura L.) Extract To Blood Glucose Level Of Rats (rattus Norvegicus) Model Diabetes Melltius Type 1 Induced By Alloxan
  2. Influence Of Onion (allium Cepa L) Ethanol Extract On White Rats Islet Langerhans (rattus Norvegicus) Induced With Alloxan
  3. The Effect Of Pomegranate Fruit Extract Standardized 40% Ellagic Acid Topically To The Collagen Density On Incision Wound In Albino Rat (rattus Norvegicus)

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