UNIVERSITAS AIRLANGGA



Detail Article

VetMedika Jurnal Klinik Veteriner

ISSN 2302-6499

Vol. 6 / No. 2 / Published : 2018-01

Order : 3, and page :10 - 14

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Original Article :

The effect of pomegranate fruit extract standardized 40% ellagic acid topically to the collagen density on incision wound in albino rat (rattus norvegicus)

Author :

  1. Bayu Dharmawan*1
  2. Tatik Herawati*2
  3. Hardany Primarizky*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The purpose of this research was to determine the effect of ointment pomegranate fruit extract (PFE) standardized 40% ellagic to collagen density on incision wound in rat. Tweenty five rats (Rattus norvegicus) with 60-90 day ages and 150-180grams average of body weight were divided into five group (P0, P1, P2, P3, and P4). P0 (control -) was not treated , P1 (control +) was treated with 10% povidone iodine , P2 was treated with PFE 40% ellagic 2,5%, P3 was treated with PFE 40% ellagic acid 5%, and P4 was treated with PFE 40% ellagic acid 7,5%. Treatment had been given directly on incision area topically for fourteen days. The data of histopatological appereance were analyzed with Kruskall-Wallis and continued with Mann-Whitney. Result showed there were significant (p<0,05) different between treatment group. Highest collagen density incision wound occurred in P4 significantly different with other group (p<0,05), giving PFE 40% ellagic acid 7,5% increasing collagen density into score 4-5. Based on the result that the average increasing of collagen density is on PFE 40% ellagic acid treatment, more high PFE 40% ellagic acid concentration more higher the compounds of flavonoid, saponin, alkaloid, tannin, anthocyandin that contains antibiotic, antiseptic, antioxidant. Ellagic acid when combined with other compositions of pomegranate also serves as a powerful antioxidants specifically anthocyanidin, is an antioxidants that can help improve blood vessels.

Keyword :

pomegranate, wound healing, collagen,


References :

Hernawati, S,(2012) Mekanisme Kerja Ekstrak Buah Delima (Punica granatum L) Terstandar Terhadap Degradasi Sel Mukosa Rongga Mulut Mencit yang Mengalami Transformasi Melalui Ekspresi BCL-2, VEGF, Wild P53 dan Apoptosis. - : Disertasi. Fakultas Kedokteran Universitas Airlangga

Nagori, B.D. and Solanki, R.,(2011) Role of Medicinal Plants in Wound Healing. 4(1) : 392-405. : Research Journal of Medicinal Plant 5.

Pirbalouti, A. G., Koohpayeh, A., and Karimi, I.,(2010) Wound Healing Activity of Flower Extracts of Punica Granatum and Achillea Kellalensis in Wistar Rats. Vol. 67 No. I pp. 107-110. : Acta Poloniae Pharmaceutica – Drug Research.

Wandari, A.,(2014) Pengaruh Pemberian ELLAGIC ACID Secara Topikal Terhadap Proses Kesembuhan Luka Insisi Pada Tikus Putih (Rattus norvegicus) Yang Diinfeksi Staphylococcus aureus. - : [Skripsi]. Fakultas Kedokteran Hewan. Universitas Airlangga. Surabaya.





Archive Article

Cover Media Content

Volume : 6 / No. : 2 / Pub. : 2018-01
  1. The Effect Of Kersen Leaf (muntingia Calabura L.) Extract To Blood Glucose Level Of Rats (rattus Norvegicus) Model Diabetes Melltius Type 1 Induced By Alloxan
  2. Influence Of Onion (allium Cepa L) Ethanol Extract On White Rats Islet Langerhans (rattus Norvegicus) Induced With Alloxan
  3. The Effect Of Pomegranate Fruit Extract Standardized 40% Ellagic Acid Topically To The Collagen Density On Incision Wound In Albino Rat (rattus Norvegicus)

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