UNIVERSITAS AIRLANGGA



Detail Article

VetMedika Jurnal Klinik Veteriner

ISSN 2302-6499

Vol. 4 / No. 2 / Published : 2016-01

Order : 4, and page :15 - 23

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Original Article :

The therapeutic effects of spirulina platensis extract on histopathological appearance of ethanol-induced kidney injury in rats (rattus norvegicus)

Author :

  1. Farah Nurfadhilla Yuantari*1
  2. Hani Plumeriastuti*2
  3. Chairul A Nidom*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The aim of this study was to prove the potential of Spirulina platensis extract in decreasing the kidney injury induced by ethanol in rats (Rattus norvegicus). Twenty male rats were divided into five groups (n = 4). They were two control group and three treatment groups which was given 200, 400, and 800 mg/kg BW of Spirulina platensis extract perorally. For the first seven days each group was given 50% ethanol 10 ml/kg BW except for control group, then continued for 14 days with Spirulina platensis extract for the treatment groups and 0.5% CMC Na solution for control groups. 24 hours after the last treatment, histopathological observation was done to score kidney injury based on the appearance of congestion, hemorrhage, degeneration, and necrosis. The data was analyzed using Kruskal Wallis and Mann-Whitney Test. The result showed that Spirulina platensis 200 mg/kg BW extract significantly decrase ethanol-induced kidney injury in rats (Rattus norvegicus) and gave significant difference (p < 0.05) among the treatment groups. 

Keyword :

Spirulina platensis, ethanol, kidney injury,


References :

Abdoloh, RN, PD Astuti, S Martono, P Hendra,(2006) Pengaruh Pra Perlakuan Beta Karoten Per Oral Terhadap Aktivitas Glutathion S-Transferase Ginjal Tikus - : Skripsi. Universitas Sanata Darma. Yogyakarta

Belay. A,(2002) The Potential Application of Spirulina (Arthrospira) As A Nutritional And Therapeutic Supplement In Health Management. . Vol. 5, No. 2, p.27-48 : The Journal of The American Nutraceutical Association

Bertolin, T.E., Pilatti, D., Giacomini, A.C., Bavaresco, C., Colla, L.M., Costa, J.A.V.,(2009) Effect of Microalga Spirulina Platensis (Arthrospira Platensis) on Hippocampus Lipoperoxidation and Lipid Profile in Rats Induced Hypercholesterolemia. 52 (5), 1253-1259 : Braz Arch Biol Technol

Gunawan,(2010) Pengaruh Pemberian Alkhohol Terhadap Derajat Nekrosis Ginjal Tikus Putih Galur Wistar. - : Perpustakaan Universitas Islam Sultan Agung.





Archive Article

Cover Media Content

Volume : 4 / No. : 2 / Pub. : 2016-01
  1. The Potential Of Kamboja Leaves Extract (plumeria Acuminata) For Angiogenesis And Pmn Cells Of Incision Wound On Mice's (mus Musculus)
  2. The Comparison Of Fluid Therapy Between Lactated Ringer's Solution And Saline 3% Toward Temperature, Pulse Rate, Respiratory Rate, And Capillary Refill Time (crt) In Domestic Cats (feline Catus) With Hypovolemia Shock
  3. The Influence Of Injecting Carbolic Acid N-butyl-2-cyano Acrylate In The Ductus Deferens As A Method Of Contraception In Rabbits
  4. The Therapeutic Effects Of Spirulina Platensis Extract On Histopathological Appearance Of Ethanol-induced Kidney Injury In Rats (rattus Norvegicus)
  5. Incidence Rate Of Dystocia In Dos At Veterinary Teaching Hospital Of Faculty Of Veterinary Medicine Universita Airlangga Period 2013-2015
  6. Comparison Of Fluid Therapy Dextran-70 And Lactated Ringer's Solution To Physiological Condition Of Body Domestic Cat (felis Catus) With Hypovolemic Shock
  7. Factors That Causing Urolithiasis In Male Cat Patients In Veterinary Teaching Hospital Faculty Of Veterinary Medicine Universitas Airlangga Period 2012-2013

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