Jurnal Respirasi
ISSN 2407-0830
Vol. 1 / No. 3 / Published : 2015-09
Order : 5, and page :103 - 108
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Original Article :
Farmakogenomik hepatotoksisitas obat anti tuberkulosis
Author :
- Andri Dwi Wahyudi*1
- Soedarsono*2
- Mahasiswa Fakultas Kedokteran
- Dosen Fakultas Kedokteran
Abstract :
Anti-TB drugs (ATD) associated with hepatotoxicity is a serious medical problem in the world, especially for patients with TB. Theproduction and expenditures toxic drug metabolites depends on the activity of some enzymes, such as N-acetyl transferase 2 (NAT2),Cytochrome P450 oxidase (CYP2E1) and Glutathione S-transferase (GSTM1). Variations from the DNA sequence or polymorphismat this locus (NAT2, CYP2E1 and GSTM1) can modulate enzyme activity and can affect the risk of hepatotoxicity. Hepatotoxicity isgenerally unpredictable and occur in a small number of patients even when the drug was given according to the recommended dosage.Among the ATD, the metabolism of INH, which is one of the ATD forefront, has been studied extensively, and said acetylation by NAT2,oxidation by cytochrome P450 oxidase (CYP2E1) and detoxified by GST play an important role in the INH-induced hepatotoxicity. Sincethe prevalence of polymorphisms is different in worldwide populations, the risk of ATD hepatotoxicity varies in the populations. Thus, theknowledge of polymorphisms at these loci, prior to medication, may be useful in evaluating risk and controlling ATD hepatotoxicity
Keyword :
pharmacogenomics, hepatotoxicity, ATD, tuberculosis,
References :
Farrell GC,(1994) Drug-induced acute hepatitis. In: Drug-induced liver disease 247–299 : UK
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 Volume : 1 / No. : 3 / Pub. : 2015-09 |
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