UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 5 / No. 1 / Published : 2005-10

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Original Article :

Peranan prolaktin sebagai immunoregulator

Author :

  1. Agustina Rahayu Magdalena*1
  2. Paulus Liben*2

Abstract :

Prolactin is neuroendocrine that is not only produced in anterior hypophyse but also on other several organ. Prolactin receptor in all of the body, include bone marrow, thymus, spleen, T-lymphosit, B-lymphosit and macrophage, play a role on immunity processes. In chronic inflammation, prolactin can reduce immunosupresif effect that caused by glucocorticoid and autoimun diseases. Prolactin increase T-lymphosit proliferation and seluler immunity. Prolactin in T-lymphosit increase IL-2 activities and IL-2 receptor. IL-2 receptor in T-lymphosit increase cytotoxin activities and IL-2 production and secretion. Prolactin also increase B-lymphosit proliferation and antibody production. Prolactin can increase monocyte differentiation and macrophage activities. Prolactin in NK cell can increase poliferation, cytotoxin activites, and also IFN production and secretion. Those show that prolactin play an important role as immunoregulator

Keyword :

prolactin, immunoregulator,


References :

Ben Jonathan N,(1996) extrapituitary prolactin: distribution, regulation, functions and clinical aspects. Endorev 17(5) - : -

M Adary,(1996) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endorev 19(3) - : -

feysot C Bole,(1998) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endorev 19(3) - : -

V Goffin,(1996) Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endorev 19(3) - : -

A D Rey,(1996) Immune-neuro-endocrine interactions: facts and hypotheses. Endorev. 17(1) - : -

R W Steinmetz,(1996) extrapituitary prolactin: distribution, regulation, functions and clinical aspects. Endorev 17(5) - : -

D L Allen,(1996) extrapituitary prolactin: distribution, regulation, functions and clinical aspects. Endorev 17(5) - : -



Archive Article

Cover Media Content

Volume : 5 / No. : 1 / Pub. : 2005-10
  1. Peranan Protein Goat Zona Pellucida-3 (gzp3) Sebagai Reseptor Fertilisasi Dan Potensinya Sebagai Kandidat Bahan Imunokontrasepsi
  2. Peranan Prolaktin Sebagai Immunoregulator
  3. Pengaruh Asam Askorbat Terhadap Kadar Imunoglobulin A Sekretori Pada Saliva
  4. Peran Fisiologis Sekresi Leptin Sebagai Dasar Pencegahan Obesitas

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