UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 5 / No. 2 / Published : 2006-02

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Original Article :

Peranan sitoskeleton menjaga stabilitas dan elastisitas membran eritrosit

Author :

  1. Agustina Rahayu M*1
  2. Tjitra Wardani*2

Abstract :

Erythrocyte has bigger diameter than capillary but erythrocyte can through the capillary. Erythrocyte membrane is very elastic so the change of shape when entering capiler not influence erythrocyte membrane structure. The strength of this membrane is caused by cytoskeleton that prop up lipid bilayer membrane. When erythrocyte enter capillary, calcium level will increase that lead into many phosphorilation. Calcium elevation more than 10-6 M will cause calcium bind with calmodulin at the end of spectrin -COOH. Calsium-calmodulin binding activate PKC in adducin and protein 4.1. Activation of PKC cause spectrin binding site in F-actin opened and make spectrin boound to F-actin and lead to spectrin  shortness. These interaction is called horizontal interaction. Calcium elevation more than 10 -7 M, is caused vertical interaction through many phosforilation processes (spectrin-ankryn-band 3, spectrin-protein 4.1-band 3, spectrin-protein 4.1-glycophorin C and spectrin - protein 4.1- band 3), that pull on lipid bilayer membrane. By this horizontal and vertical interactions, erythrocyte membrane become stable and elastic when entering capillary.

Keyword :

cytoskeletal, erythrocyte, calcium, capillary,


References :

J P Anderson,(1987) The interaction of calmodulin with human erythrocyte spectrin. J Biochem 262 - : -

JS Morrow,(1987) The interaction of calmodulin with human erythrocyte spectrin. J Biochem 262 - : -

V Bennett,(0000) spectrin and ankyrin based pathways: metazoan inventions for integrating cells into tissues. Am J Physiol 81 - : -

A Baines,(0000) spectrin and ankyrin based pathways: metazoan inventions for integrating cells into tissues. Am J Physiol 81 - : -

S H Chang,(2001) Regulation of the glycophorin C-protein 4.1 membrane to skeleton bridge and evaluation of its contribution to erythrocyte membrane stability. J Biochem 276 - : -

P S Low,(2001) Regulation of the glycophorin C-protein 4.1 membrane to skeleton bridge and evaluation of its contribution to erythrocyte membrane stability. J Biochem 276 - : -

RH Chen,(1997) The role of the PH domain in the signal-dependent membrane targeting of Sos. EMBO Journal 16 - : -

G S Corbalan,(1997)



Archive Article

Cover Media Content

Volume : 5 / No. : 2 / Pub. : 2006-02
  1. Peranan Sitoskeleton Menjaga Stabilitas Dan Elastisitas Membran Eritrosit
  2. Pengaruh Perubahan Letak Titik Berat Dan Titik Tumpu Tubuh Kerja Bubut Posisi Berdiri Ergonomis Terhadap Kelelahan Otot Biomekanik
  3. Study Of Some Biochemical Parameters In Young Man As Effected By Ramadan Fasting
  4. Pengaruh Curcumin Terhadap Kekuatan Kontraksi Jantung Tikus Betina Yang Diperlakukan Iskemia – Reperfusi Dengan Metode Langendorff
  5. Plasticity Biologis Sel Imunokompeten Pada Pemberian Dexamethason
  6. Peran Leptin Dalam Meningkatkan Densitas Tulang

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