UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 9 / No. 2 / Published : 2010-02

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Original Article :

The effect of regular exercise and estrogen replacement therapy on the duration of heart’s muscle repolaritation after bilateral ovariectomized sprague dawley mice

Author :

  1. Denny Agustiningsih*1
  1. Bagian Ilmu Faal Fakultas Kedokteran UGM

Abstract :

After the menopausal stage, the nature of electricity in women's heart will change. As the decrease of estrogen, the rate of arrythmia and the mortality caused by arrythmia increases. Prolonged time repolarization of the cardiac's muscle is assumed to be the caused of arrythmia in menopausal women. The prolonged time of repolarization can be observed from ECG. The ECG shows leghtening of QTc interval. The aim of this research is to compare the effect of regular medium dose of exercise on the shortening of cardiac's muscle repolarization, on bilateral ovariectomized mice and estrogen replacement therapy mice. The subjects of this study are 24 Spraque Dawley mice, aged 40-50 days. From the study we conclude that regular swimming for 1 hour, 5 times a week for 10 weeks can cause the shortening of cardiac's muscle repolarization in bilateral ovariectomized mice. The estrogen replacement therapy to the mice after bilateral ovariectomy can prevent the prolonged repolarization of cardiac's muscle. The combination of swimming and estrogen replacement therapy can also prevent the prolonged repolaritation of mice's cardiac's muscle after bilateral ovariectomy.

Keyword :

Exercise, Ovariectomized, estrogen, QT interval, repolarization,


References :

Billman GE,(2002) Aerobic exercise conditioning: a non-pharmacological anti-arrhythmic intervention - : J Appl Physiol





Archive Article

Cover Media Content

Volume : 9 / No. : 2 / Pub. : 2010-02
  1. Immune Reaction To The Eating And Drinking Fasting Induced Stress
  2. A New Concept Of Chronic Heart Failure
  3. The Effect Of Giving Lidah Buaya (aloe Vera) Juice To Decrease Amount Of Blood Glucose And Triglycerides In Rattus Norvegicus Induced By Alloxan
  4. The Effect Of Leaf Katuk Powder (sauropus Androgynus) In Broiler Chicken Feeding In Feed Digestibility, Bodyweight, And Bile Production
  5. Polymorphisms Of T/c 8002 Endothelin-1 Gene, Body Mass Index And Gestational Hypertension
  6. Effect Of Plasma Angiotensin Converting Enzyme (ace) In Erectile Dysfunction
  7. Anti Diabetic Effects Of Boiled Sea Jujube On White Rats Induced Alloxan
  8. Myoglobin Gene Expression Of Soleus, Gastrocnemius And Cardiac Muscles After Aerobic And Anaerobic Exercise In Wistar Rat
  9. The Effect Of One Session Physical Exercise To Interleukin 6 And Von Willebrand Factor Blood Level In White Rat (rattus Novergicus Strain Wistar)
  10. The Effect Of Active Recovery In Warm Water On The Reduction Of Post-exercise Blood Lactic Acid Concentration On White Rat (rattus Norvegicus)
  11. The Effect Of Regular Exercise And Estrogen Replacement Therapy On The Duration Of Heart’s Muscle Repolaritation After Bilateral Ovariectomized Sprague Dawley Mice
  12. The Application Of Ergonomical Aspect In Sport : The Influnce Of The Length Of The Hand To The Distance Of The Toss In Sma I Kediri Tabanan Students

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