UNIVERSITAS AIRLANGGA



Detail Article

Majalah Ilmu Faal Indonesia

ISSN 0215-1995

Vol. 7 / No. 1 / Published : 2007-10

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Original Article :

Uji klinis transforming growth factor 1sebagai tissue engineering padaperawatan direct pulp capping

Author :

  1. Sri Kunarti*1
  1. Departemen Konservasi Gigi Fakultas Kedokteran Gigi Universitaas Airlangga

Abstract :

Dental pulp therapy of teeth degraded by caries, dental wear lesions or trauma in currently limited to conventional restoration such as pulp capping or root canal therapy. Therefore, dental research focusing on strategies for vital pulp therapy by maintaining the function of the teeth. The implementation of a medical device in dental and oral tissue engineering is based on potensial cell sources and biocompatible materials applied as direct pulp capping agents, wich can also serve as a carrier of signaling molecules in addition to nerves and blood vessels, the pulp contains highly prolifrative stem/progenitor cells possessing a self renewal and differentiation capability. Methods. These researches were in-vitro in fibroblast tissue culture of BHK and in-vivo from orthodontic patients indicated for premolar extraction, between ages 10 – 15 years. A class V cavity preparation was created in the buccal aspect 1 mm above gingival margin until pulp exposure. Cavity was irrigated slowly with saline solution and dried with a sterile small cotton pellet. The sterile absorbable collagen membrane used, as inert carrier of TGF-1 was soaked with 5 l. TGF-1 was covered by a teflon pledge to separate pulp capping agent from restoration of Glass Ionomer Cement. Results. In-vitro there was 30ng/ml of TGF-1 was highest absorbance in spectrophotometer, and in-vivo was occur inflammation in pulp fibroblast. In further clinical trial experiment there was 20ng/ml not occurring inflammation symptom. Conclusion. In-vitro experiment of exogenous TGF-1 on BHK tissue culture only for estimating to clinical trial, and the same consentration of TGF-1 applied to human fibroblast cause inflammation symptoms.

Keyword :

Progenitor cell, direct pulp capping, TGF-1, tissue engineering,


References :





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2007-10
  1. Perubahan Kadar Laktat Darah Akibat Manipulasi Sport Massage Dan Circulo Massage Setelah Latihan Fisik
  2. Traditional Circuit Training Dan Kebugaran Fisik Mahasiswa
  3. Perbandingan Kemampuan Fisik Antara Atlet Pencak Silat Kategori Tanding Dengan Kategori Seni Pada Pelatda Pon Xvii Di Jawa Barat
  4. Kajian Aktivitas Imunostimulan Dari Ekstrak Air Bawang Putih (allium Sativum)
  5. Pemberian Teh Hijau (camellia Sinensis) Terhadap Jumlah Sel Radang Kronis Dan Limfosit T–cd4
  6. Fluktuasi Tekanan Darah, Kadar Endothelin-1 (et-1),dan Nitric Oxide (no) Pada Kehamilan Normal
  7. Profil Serologis Virus Dengue Yang Menginduksi Infeksi Primer Dan Sekunder Dari Beberapa Area Di Jawa Timur
  8. Uji Klinis Transforming Growth Factor 1sebagai Tissue Engineering Padaperawatan Direct Pulp Capping
  9. Peran L-karnitin Dalam Memfasilitasi β-oksidasi Di Mitokondria
  10. Perubahan Gustducin Dan Neutrofil Pada Keadaan Demam
  11. Hipnoterapi Sebagai Analgesik Nyeri Gigi

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