UNIVERSITAS AIRLANGGA



Detail Article

Media Kedokteran Hewan

ISSN 2015-8930

Vol. 24 / No. 1 / Published : 2008-01

Order : 11, and page :63 - 67

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Original Article :

The increase of desidual macrophages activity in infected toxoplasma gondii pregnant mice

Author :

  1. Lucia Tri Suwanti*1
  1. Dosen Fakultas Kedokteran Hewan

Abstract :

The objective of this study was to know the effect of Toxoplasma gondii infection to the increase of macrophages activity in pregnant mice decidua. Forty-eight pregnant Swiss mice were divided into 6 groups. Group I, first week gestation non-infected mice. Group II, first week gestation infected mice. Group III, second week gestation non-infected mice. Group IV, second week gestation infected mice. Group V, third week gestation non-infeceted mice and group VI, third week gestation. Infected mice. Mice were infected with 1 x 103 tachyzoites by intraperitoneal. Four days post infection, mice were sacrificed and placenta was removed to observe the macrophages activity. The increase of macrophages activity in pregnant mice deciduas was determined by the increase of TNF-α expression in decidual macrophages by using immunohistochemistry method. The data were analysed by ANOVA. In comparison with uninfected mice, macrophages activity significantly increased in infected mice decidua(P<0,01). By LSD post hoc test, all groups were significantly difference. In infected mice, TNF-α expression in first, second, and the third week gestation were 35.59%, 30.47%  and 30.18% and in uninfected mice were 23.99%, 14.12%, and 10.64%. This study concluded that Toxoplasma gondii infection effected to the increase of decidual macrophages activity

Keyword :

Decidual macrophage, Toxoplasma gondii, TNF-α,


References :

Baines MG,(2002) Immunology of Pregnancy - : Documen Online: http:// www. Nicroimm. Mcgill. Ca. Pdf. Diakses tanggal 14-09-2003 jam 23.10

Bohne W, Heesemann J, Gross U,(1994) Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: a possible role for nitric oxide in triggering stage conversion - : Infect. Immun. 62: 1761-1767

Deckert-Schluter M, Bluethmann H, Rang A, Hof H, and Schluter D,(1998) Crucial Role of TNF Receptor Type 1 (p55), But Not of TNF Receptor Type 2 (p75), in Murine Toxoplasmosis - : J. Immunol. 160: 3427-3436

Denkers EY, Gazzinelli RT,(1998) Regulaion and Function of T-Cell-Mediated Immunity during Toxoplasma gondii Infection - : Cli. Microbiol. Rev; 11: 569-588

Dubey JP, Lindsay DS, Speer CA,(1998) Structures of Toxoplasma gondii Tachyzoites, Bradyzoites, and Sporozoites and Biology and Development of Tissue Cysts - : CMR, 11 (2): 267-299

Fried M, Muga RO, Misore AO, Duffy PE,(1998) Malar



Archive Article

Cover Media Content

Volume : 24 / No. : 1 / Pub. : 2008-01
  1. Antigenecity, Sensitivity And Spesificity Of 27-28 Kda Protein Of Fasciola Spp Excretory-secretory (es) Material For Distomatosis Diagnosis In Cattle Sera By Using Indirect-elisa Technique
  2. Detection Of Toxoplasma Gondii On The Local Chicken Eggs Sold As The Mixture Of Traditional Medicine In Surabaya Using Biological Test
  3. Identification Of Avian Reovirus In Chickens With Tenosynovitis Using Indirect Sandwich-elisa And Protein Characterization By Western Blot
  4. The Inhibition Of Vitamin E (α- Tocopherol ) Antioxidant To Superoxide Radical Reactive Oxygen Species (o2.-) Production On The White Rat (rattus Norvegicus)stressed By An Electric Shock
  5. Intravenous Phosphate Infusion Results In Hyperphosphatemia And Hypocalcemia Without Changing In Plasma Parathyroid Hormone And Calcitriol Concentrations In Goats
  6. Ultrasonography Diagnostic For Detection Of The Uterus Disorders In Cats (felis Catus)
  7. Potency Of Mengkudu (morinda Citrifolia) Juice Extraction On Carcass Quality, Vitamin C Level And Malonedialdehide (mda) Level In Broiler’s Blood
  8. Comparison Of Fertility Of Etawa Crossbred Goats In Low Versus Ideal Body Condition Score After Estrus Synchronization And Artificial Insemination
  9. Digestibility And Consumption Of Dry Matter And Organic Matter In Haylage Complete Feed Ongole Crossbreed Steers
  10. The Increase Of Desidual Macrophages Activity In Infected Toxoplasma Gondii Pregnant Mice
  11. Restricted Feeding Delayed Sexual Maturation, Decrease Biometry Of Reproductive Organ And Fat Deposition Of Quail Hens (coturnix Coturnix Japonica)
  12. Detection Of Toxoplasma Gondii On The Local Chicken Eggs Sold As The Mixture Of Traditional Medicine In Surabaya Using Biological Test
  13. The Increase Of Desidual Macrophages Activity In Infected Toxoplasma Gondii Pregnant Mice

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