UNIVERSITAS AIRLANGGA



Detail Article

Media Kedokteran Hewan

ISSN 2015-8930

Vol. 18 / No. 2 / Published : 2002-12

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Original Article :

Uji efek depresi sistem saraf pusat ekstrak kulit batang orang aring (fraxinus graffithii clarke) pada mencit

Author :

  1. Setiawan M.W*1
  2. Basori A*2
  3. Mariana S*3
  1. Fakultas Farmasi Unika Widya Mandala, Surabaya
  2. Fakultas Kedokteran Universitas Airlangga
  3. )Fakultas Farmasi Unika Widya Mandala, Surabaya

Abstract :

A 95 % etanol extract of Orang Aring bark (Fraxinus graffithii Clarke) has been investigated for the effetct on CNS depression. Adult male mice of Swiss Webster strain at oral doses of 1,5 g, 2,0 g and 2,5 g/kg body weight was used to find the CNS depresant effect. Time Peak Effect was first measured with the extract dose 2,0 g/kg body weight and thiopental 40 mg/kg body weight intraperitoneal to induce the hipnotic effect. Barbiturate sleeping time for all groups was observed at time peak effect. Motoric activity also observed at time peak effect by the using activity cage and Motoric coordination effect observed by Rota Rod. Further more, it has been verified by regression analysis, the correlation between dose and effect. The results shown that time peak effect extract of Fraxinus griffithii Clarke at the dose 2,0 g/kg body wight was 60 minutes. Duration of action observed Barbiturate sleeping time for CMC Na 1 % was around 2.200 seconds while for all dose of the extract was more than 3.000 seconds. Acitivity cage measurement shown decreased on motoric activity in 60 – 180 minutes after all dose extract administration. Motoric coordination effect observed by Rota Rod at the dose 3.000 mg/kg body weight shown that all the mice can stand for more than 1 minute at 8 rpm.

Keyword :

Fraxinus Griffithii Clarke, CNS Depression, mice.,


References :





Archive Article

Cover Media Content

Volume : 18 / No. : 2 / Pub. : 2002-08
  1. Uji Efek Depresi Sistem Saraf Pusat Ekstrak Kulit Batang Orang Aring (fraxinus Graffithii Clarke) Pada Mencit
  2. Study Of Gastointestinal Nematodes Investing Sheep At The Banda Aceh Slaugtherhouse
  3. Measurement Progesterone Profile As A Method To Early Pregnancy Diagnoses And Twinning Birth On Local Ewes
  4. A Model For Calculating Economic Lost Due To Animal Disease Cases Foot And Mouth Disease
  5. Concentration Of Total Protein, Calcium, And Protein Fractions In The Blood Plasma Of Aceh Sumatran Elephants (elephas Maximus Sumatranus)
  6. Androgenic And Anabolic Effects Of Testosterone On Day Old Chick
  7. Increasing The Quality Of Gouramy Fry (osphronemus Gouramy) By Male Monosex Method
  8. Blood Cholesterol Of Hypercholesterolemic Rats Given Eggs Supplemented Diet With Omega-3 Fatty Acids, Lecithin And Vitamin E
  9. The Nutritif Value Of Tofu Waste-rice Bran And Tofu Waste-pollard Which Was Fermented With Rhyzopus Microsporus Var. Oligosporus
  10. The Use Of “effective Microorganism” Against The Protein Digestibility In Broiler
  11. The Antelminthic Effect Of Garlic (allium Sativum Linn) Against Ascaridia Galli Infection In Chicken (gallus Gallus)
  12. Monoclonal Antibody Production Against Dengue Virus Surabaya Isolate
  13. Increasing The Quality Of Gouramy Fry (osphronemus Gouramy) By Male Monosex Method

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