UNIVERSITAS AIRLANGGA



Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 19 / No. 2 / Published : 2011-05

Order : 5, and page :78 - 80

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Original Article :

Intraamniotic infection diagnostic test in pprom through the measurement of vaginal fluid c-reactive protein using hs-crp check-1 (lateral-flow immunoassay method) with cobas integra 400 plus (light-scattering immunoassay method) as a gold standard

Author :

  1. Muhammad Novan Affandy*1
  2. Aditiawarman*2
  1. Mahasiswa Fakultas Kedokteran
  2. Dosen Fakultas Kedokteran

Abstract :

Intraaamniotic infection increased perinatal morbidity and mortality. Intraamniotic infection can be established from vaginal fluid CRP concentrations measurement. There are several methods to measure CRP in body fluid, one of the simplest method is the lateral-flow immunoassay. However the reliability of this test should be compared to the more sophisticated method by knowing the equality of HS-CRP CHECK-1 to Cobas Integra 400 Plus in measuring vaginal fluid CRP and detecting intraamniotic infection as well as knowing the sensitivity, specificity, positive predictive value and negative predictive value of HS-CRP CHECK-1 for detecting intraamniotic infection. The objective of this study was to prove HS-CRP CHECK-1 can be used to measure the levels of CRP in vaginal fluid and can be used as a diagnostic tool for intraamniotic infection. This was diagnostic test research, 33 sample of vaginal fluid from PPROM patients are analyze using HS-CRP CHECK-1 and Cobas Integra 400 Plus as the gold standart. Intraamniotic infection is determined by CRP level > 0.8 mg/L. Test results were then compared and analyzed. From the statistical analysis, it was found that HS-CRP CHECK-1 is equivalent to Cobas Integra 400 Plus in measuring vaginal fluid CRP and diagnosing intraamniotic infection. Sentifity 50%, spesificity 100%, positive predictive value 100% and negative predictive value 86.2% are obtained from HS- CRP CHECK-1 for intraamniotic infection. In conclusion, HS-CRP CHECK-1 is equivalent to Cobas Integra 400 Plus, and can be used as a diagnostic test. (MOG 2011;19:78-80)

Keyword :

HS-CRP CHECK-1, CRP, Intraamniotic infection, PPROM, -,


References :

Merenstein GB and Weisman LE,(1996) Premature rupture of the membranes: neonatal consequences - : Semin Perinatol

Di Naro E, Ghezzi F, Raio L, Romano F, Mueller MD, McDougall J, et al,(2003) C- reactive protein in vaginal fluid of patients with premature rupture of membranes - : Acta Obstet Gynecol Scand





Archive Article

Cover Media Content

Volume : 19 / No. : 2 / Pub. : 2011-05
  1. Perbandingan Ekspresi P16ink4a Antara Pap Smear Low Grade Squamous Intraepithelial Lesion Dengan High Grade Squamous Intraepithelial Lesion
  2. Comparison Between Early-onset And Late-onset Preeclampsia By Echocardiographic Examination Of Cardiac Output, Total Vascular Peripheral Resistance, And Doppler Velocimetry Examination Of Uterine Artery Resistance Index
  3. Comparison Of Pap Smear Examinations Result Between Post Leep And Electrocauter In Low-grade Squamous Intraepithelial Lesion Patients
  4. Increased Expression Of Myocyte Hsp27 And Myometrium Contraction On New Zealand Rabbit Following Surabaya Method Uterine Compression Suture After Cesarean Delivery
  5. Intraamniotic Infection Diagnostic Test In Pprom Through The Measurement Of Vaginal Fluid C-reactive Protein Using Hs-crp Check-1 (lateral-flow Immunoassay Method) With Cobas Integra 400 Plus (light-scattering Immunoassay Method) As A Gold Standard
  6. Perbandingan Antara He4,ca-125, Dan Kombinasi He4 & Ca-125 Sebagai Tumor Marker Pada Pasien Kanker Ovarium Tipe Epitel
  7. Profil Kadar Kit-ligand Pada Zalir Folikel Ovarium Pada Pasien Infertil Dengan Endometriosis Ringan, Berat Dan Tanpa Endometriosis

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