UNIVERSITAS AIRLANGGA



Detail Article

Majalah Obstetri & Ginekologi

ISSN 0854-0381

Vol. 16 / No. 3 / Published : 2001-01

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Original Article :

Ratio of bcl-2/bax expression and the changing of endometrial gland of rattus novergicus at a model of pcos with flutamide and mpa therapy

Author :

  1. Laurens David Paulus*1
  2. Budi Santoso*2
  3. Widjiati*3
  1. -
  2. -
  3. -

Abstract :

The objective of this research is confirming difference in Bcl-2/Bax expression ratio, endometrial gland count after administration of flutamide, medroxyprogesterone acetate and placebo in Rattus novergicus strain Wistar hiperandrogen as a PCOS model. The research was taken place at Animal Test and Pathology Anatomy Department in Veterinary Faculty, Airlangga University, November 2007 until January 2008 period, as approved by Animal Research Ethics Commitee, Veterinary Faculty, Airlangga University. The design was experimental research with randomized post test only control group design. Sample are consecutively recruited based on inclusive criteria and analyzed with Anova test as well as double comparation test using LSD (Least Square Difference). The result are from three treatment groups Rattus novergicus strain Wistar hyperandrogen as SOPK models were found mean ratio of Bcl-2/Bax expression in P2 group (flutamide administered) is lower compared to P1 (placebo) and P3 (medroxyprogesterone acetate administered) (P1; 1.9 ± 0.3, P2; 1.06 ± 0.4, P3; 1.2 ± 0.2, p < 0.0001). Mean of endometrial gland count in P2 group is lower compared to other group (P1; 8.5 ± 0.3, P2; 5.4 ± 0.2, P3; 6.4 ± 0.3, p < 0.0001). The conclusion is we found significant difference in Bcl-2/Bax expression and endometrium gland count on all three study group. Endometrium Hyperplasia is lower on P2 group (flutamide administered) compared to P3 group (MPA administered).

Keyword :

PCOS, endometrium hyperplasia, flutamide, medroxyprogesteron acetate, Bcl-2/Bax expression, endometrium gland count,


References :

Harwood K, Vuguin P, Dimartino-Nardi J,(0000) Current approaches to the diagnosis and treatment of polycystic ovarian syndrome in youth :





Archive Article

Cover Media Content

Volume : 16 / No. : 3 / Pub. : 2008-09
  1. Comparison Of Neutropenia And Peripheral Neuropathy Incidence With Paclitaxel Infusion 3 Hours Vs 24 Hours In Adjuvant Therapy With Paclitaxel – Carboplatin In Ovarian Carcinoma
  2. Comparison Of Brain Derived Neurotrophic Factor (bdnf) Serum Level Of Newborn Placenta Between Pregnant Woman Either Obtained Docosahexaenoic Acid (dha) Or Not
  3. Ratio Of Bcl-2/bax Expression And The Changing Of Endometrial Gland Of Rattus Novergicus At A Model Of Pcos With Flutamide And Mpa Therapy
  4. Successful Management Of Pregestational Dm With Severe Complications
  5. A Case Of Trap Sequence At Dr. Soetomo General Hospital

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