UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Rekonstruksi & Estetik

ISSN 2301-7937

Vol. 2 / No. 1 / Published : 2013-01

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Original Article :

Bactericidal effect of topical vitis vinifera on methicillin-resistant staphylococcus aureus (mrsa) on rattus norvegicus skin wound

Author :

  1. Beatrix Curie Panjaitan*1
  2. Lobredia Zarasade*2
  3. M. Sjaifuddin Noer*3
  1. mahasiswa
  2. dosen
  3. dosen

Abstract :

Introduction : Methicillin Resistant Staphylococcus Aureus (MRSA) is one of the most common pathogens worldwide that can cause variety of skin and soft tissue infection and can be fatal causing septicemia. Searching for drug and chemical compounds against MRSA is still in demand.  Grape is consumed widely around the world, and the seed  (Vitis Vinifera) is considered as a waste product but in study in vitro proven to be a rich source of polyphenolic compounds that show antibacterial effect against MRSA. The aim of this study is to investigate the antibacterial effect of grape seed extract  on MRSA on white rat (Rattus norvegicus) Wistar strain skin wound and compare the antibacterial effect to mupirocin’s effect on MRSA. Methods : Experimental research design using posttest only control group design. The wound at the back site of 27 healthy male white rats Wistar strain (Rattus norvegicus) inoculated with MRSA. The swab specimens taken 6 hours after inoculation of MRSA, on day 1 and day 3 after the treatment with grape seed extract (Vitis vinifera) and mupirocin.for microbiological examination to count the number of colonies.  Result : On all of the wounds in which were applied topical grape seed extract, the number of colonies of MRSA was significantly raised with respect to the control in 1x24 hours (p<0,005) and decreased (p< 0,0001) after 3x24 hours, while treated with mupirocin significantly decreased within 1x24 hours. Discussion : Grape seed extract has antibacterial effect, but it has slower effect compared to mupirocin

Keyword :

MRSA, antibacterial effect, Vitis vinifera, polyphenolic,


References :

P. Graham, S. Lin and E.Larson,(2006) A US population-based survey of staphylococcus aureus colonization New York : Annals of Internal Medicine

A. Alex, M. Letizia,(2007) Community-acquired methicillin-resistant Staphylococcus aureus: Considerations for school nurses New York : J of School Nursing

J.Hinckley and PJ Allen,(2008) Community-associated MRSA in the pediatric primary care setting New York : Pediatric Nursing

H.Huang et al,(2006) Comparisons of community - associated methicillin - resistant Staphylococcus aureus (MRSA) and hospital-associated MRSA infections in Sacramento, California California : J of Clinical Microbiology





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-01
  1. The Effect Of Intravenous Vitamin C On Nitric Oxide Serum Level In Severe Burn Injury
  2. Effectivity Of Topical Chitosan On Exudative Chronic Wound Management
  3. Bactericidal Effect Of Topical Vitis Vinifera On Methicillin-resistant Staphylococcus Aureus (mrsa) On Rattus Norvegicus Skin Wound
  4. Pengaruh Pemberian Topikal Low Molecular Weight Hyaluronate Pada Epitelialisasi Luka Superfisial Tikus Putih Yang Dirawat Dengan Membran Amnion Freeze-dried
  5. The Effect Of 3000 Mg Vitamin C Infusion On Histamine Level In Severely Burned Patients
  6. The Effect Of Amnion Freeze – Drying To Prevent Adhesion In Rabbit Tendon Achilles Healing
  7. Five Years Retrospective Study Of Burns In Dr. Soetomo General Hospital Surabaya
  8. Analyzing Post-reconstruction Facial Anthropometric, Cephalometric Parameters And Proportion Of Facial Edema On Maxillofacial Trauma Patients
  9. The Nasal Profile Of Young Indonesian Women Aged 19-21 Years Old Judged To Be Atractive According To Third Year Medical Students Of Airlangga University
  10. Eye Profile Of Indonesian Young Women Aged 19-21 Years Judged To Be Attractive By Third Year Medical Students Of Airlangga University

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