UNIVERSITAS AIRLANGGA



Detail Article

Jurnal Rekonstruksi & Estetik

ISSN 2301-7937

Vol. 2 / No. 1 / Published : 2013-01

Related with : Scholar   Yahoo!   Bing

Original Article :

The effect of intravenous vitamin c on nitric oxide serum level in severe burn injury

Author :

  1. Lobredia Zarasade*1
  2. Bobby Swadharma Putra*2
  3. M. Sjaifuddin Noer*3
  1. dosen
  2. mahasiswa
  3. dosen

Abstract :

Introduction: Nitric oxide (NO) has a potential rule in pathogenesis of causingsystemic hypotension and apoptosis, contributing to tissue damage and multiple organ failure in severe burn. Severe Burn  increases the activity of the Nitric Oxide Syntase (NOS) enzyme and Nitric Oxide release. Proinflamatory cytokines is inflammatory mediators implicated in the induction and activation of NOS and NO release also. Vitamin C work as antioxidant by providing hydrogen ions to free radical into stable molecule and blockade the activation of NF-kB  so that suppresses  proinflamatory cytokines production and  Nitric Oxide production can be inhibited. The purpose research To review the effect of intravenous vitamin C3000mg on Nitric Oxide serum Level in severe burn injury patient post fluid resuscitation.                                     .                                                                                   Method: Randomized pre test and  post test controlled group design experimental studied on 12 severe burns patient at the Burn Unit of Dr. Soetomo Hospital in Surabaya who have been treated with baxter formula. Nitric Oxide examined in 12 patient. Divided into 2 groups K 1as the control groupwith vitaminC 2x400mg/24 hour for 72hours ; K2, administrered with intravenous  vitamin C 3000 mg for 72 hours . Nitric oxide then re-examined.  Nitric Oxide was taken from blood serum and observed by Grease method. The results were analyzed by Paired T-Test and statistical assays, with reliability p < 0,05.   Result :Serum levels  NO in the control group(K1) no significant increase in the serum levels of NO compared to the first day of the fourth day (p=0,21) and no significant decrease in serum levels of NO in the first day than the serum levels of NO on the fourth day (K2)(p=0,06). There is a statistically significant decrease in the levels of NO in the group given intravenous vitaminc 3000mg/24hours for 72 hours (K2) comparison with a control group(K1) (p=0,02). From groups K 1as the control group there were no significant result in Blood Gas Analisis(BGA), Blood Urea Nitrogen (BUN), and Serum Creatinine (SC). In the groups K 2 as administrered with intravenous  vitamin C 3000mg for 72 hours there were significant result in White Blood Cell(WBC) (p=0,01).   Conclusion: Research is a significant decrease in the levels of NO in the group that was given intravenous vitaminc3000mg/24 hours for 72 hours comparison with a control group given in travenous vitaminc 2x400 mg/24 hours  for 72 hours 

Keyword :

vitamin c, severe burn, nitric oxide,


References :

Bogdan C,(2001) Nitric oxide and the immuneresponse New York : Nature immunology

Alderton W, Cooper C,(2001) Nitric oxide synthases : structure, function and inhibition New York : J Biochem

Arturson G,(1996) Pathophysiology of burn wound and pharmacological treatment: The Rudi Hermans Lecture New York : Burn





Archive Article

Cover Media Content

Volume : 2 / No. : 1 / Pub. : 2013-01
  1. The Effect Of Intravenous Vitamin C On Nitric Oxide Serum Level In Severe Burn Injury
  2. Effectivity Of Topical Chitosan On Exudative Chronic Wound Management
  3. Bactericidal Effect Of Topical Vitis Vinifera On Methicillin-resistant Staphylococcus Aureus (mrsa) On Rattus Norvegicus Skin Wound
  4. Pengaruh Pemberian Topikal Low Molecular Weight Hyaluronate Pada Epitelialisasi Luka Superfisial Tikus Putih Yang Dirawat Dengan Membran Amnion Freeze-dried
  5. The Effect Of 3000 Mg Vitamin C Infusion On Histamine Level In Severely Burned Patients
  6. The Effect Of Amnion Freeze – Drying To Prevent Adhesion In Rabbit Tendon Achilles Healing
  7. Five Years Retrospective Study Of Burns In Dr. Soetomo General Hospital Surabaya
  8. Analyzing Post-reconstruction Facial Anthropometric, Cephalometric Parameters And Proportion Of Facial Edema On Maxillofacial Trauma Patients
  9. The Nasal Profile Of Young Indonesian Women Aged 19-21 Years Old Judged To Be Atractive According To Third Year Medical Students Of Airlangga University
  10. Eye Profile Of Indonesian Young Women Aged 19-21 Years Judged To Be Attractive By Third Year Medical Students Of Airlangga University

Information index.php/JIPK/tmp_tumb/RE