UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 10 / No. 1 / Published : 2017-02

Order : 3, and page :15 - 22

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Original Article :

Potency of curcumin on histopathological changes in the kidney of pregnant mice (mus musculus) exposed to cadmium

Author :

  1. Afifah*1
  2. Widjiati*2
  3. Thomas Valentinus Widiyatno*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

Cadmium is a heavy metal that is toxic to humans. Curcumin is the yellow pigmentderived from Curcuma longa that has antioxidant activity. The purpose of this study is todetermine the potency of curcumin on histopathological changes in the kidney of pregnantmice (mus muscululus) exposed to cadmium. 20 pregnant mice were divided into fourgroups. P0 were injected aquadest + 0.5% CMC Na liquid. P1 were injected by cadmiumchloride 4.5 mg/kg BW + 0.5% CMC Na liquid. P2 were injected by cadmium chloride4.5 mg/kg BW + curcumin 150 mg/kg BW. P3 were injected by cadmium chloride 4.5 mg/kg BW + curcumin 300 mg/kg BW. On the 17th day of gestation, all mice were sacrificedfor histopathological examination. The data was analyzed by Kruskal-Wallis test andfollowed by Z test. Giving curcumin doses of 300 mg/kg BW can repair picnosis andhydropic degeneration on kidney histopathology. Curcumin as antioxidant dan chelatingagents.The results showed that curcumin can reduce the histological damage of pregnantmice kidney which had been exposed to cadmium.

Keyword :

Cadmium, Curcumin, Kidney histophatology, pregnant mice,


References :

Abu-Taweel, Gasem M., J. S. Ajarem, and M. Ahmad,(2013) Protective Effect of Curcumin on Anxiety, Learning Behavior, Neuromuscular Activities, Brain Neurotransmitters and Oxidative Stress Enzymes in Cadmium Intoxicated Mice.. 3: 74-84 : Journal of Behavioral and Brain Science

Ak, T., I. Gulcin,(2008) Antioxidant And Radical Scavenging Properties Of Curcumin 174: 27–37. : Chemico-Biological Interactions

Dutta, S., S. Padhye, K.I. Priyadarsini, and C. Newton,(2005) Antioxidant And Antiproliferative Activity Of Curcumin Semicarbazone 15: 2738–2744 : Bioorganic & Medicinal Chemistry Letters





Archive Article

Cover Media Content

Volume : 10 / No. : 1 / Pub. : 2017-02
  1. Isolation And Identification Vibrio Sp As Vibriosis Cause Of Agent At Grouper Fish (epinephelus Fuscoguttatus) In Banyuwangi Regency
  2. Identification Of Species And Stage Of Mite Causes Scabies By Crusting Severity On The Rabbits
  3. Potency Of Curcumin On Histopathological Changes In The Kidney Of Pregnant Mice (mus Musculus) Exposed To Cadmium
  4. Effect Of Vitamin C And E Towards Histopathological Changes Of Duodenum In Mice Induced With Borax
  5. The Effects Of Crude Protein Bovine Seminal Plasma Addition In Skim Milk And Egg Yolk Diluent To Motility, Viability, Dna Fragmentation, And Necrosis Of Ram Spermatozoa After Equilibration
  6. The Effect Of Red Fruit Oil (pandanus Conoideus Lam.) On Histopathology Of Follicle Development In Infertile Mice Modelling
  7. Prevalence And Infection Level Of Gastrointestinal Worm Nematode On Long Tailed Macaque (macaca Fascicularis) At Taman Wisata Wendit Malang Regency
  8. Prevalence Of Distomatosis On Various Type Of Slaughtered Cattle At Penggaron Semarang Abattoir
  9. Pattern Of Antibiotics Resistance On Escherichia Coli That Isolated From Raw Milk In Surabaya
  10. Effect Of Mangosteen (garcinia Mangostana Linn.) Pericarp Extracts On The Diameter Of Mice (mus Musculus) Pre Antral And Antral Follicles
  11. Semen Quality, Hsp 70 Expression And Dna Damage Of Post Thawing Limousine Bull Spermatozoa After Cooled At 5 °c
  12. The Effects Of Propolis On Histological Liver In Male Mice (mus Musculus)
  13. Effect Of Rosella Flower (hibiscus Sabdariffa L.) Extract On Liver Histhopathologic Of Male Mice (mus Musculus) Exposed Plumbum Acetate
  14. Effect Of Electrical Field On The Death Of Staphylococcus Aures In Milk
  15. The Effect Of Mimosa Pudica Root Extract To Histopathological Representation Of Rattus Norvegicus Liver Injected With Naja Sputatrix Venom
  16. Androgen Dihydrotestosterone And Its Role In Male Reproductive System

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