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Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 1 / Published : 2014-02

Order : 12, and page :73 - 80

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Original Article :

Potential mycotoxin binders on histopathology of the mammary gland experiencing neoplasia in pregnant mice (mus musculus) with exposed zearalenone

Author :

  1. Muhammad Thohawi Elziyad Purnama*1
  2. Abdul Samik*2
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan

Abstract :

Zearalenone is a resorcylic acid lactone compound that is produced by fungal Fusarium graminearum infection of edible grains and is believed to influence reproduction by binding to estrogen receptors. In order to study the potential estrogenic effect of this compound in the mammary gland, we examined the potential of mycotoxin binders to eliminate the effect of zearalenone on the expression of histopathology of the mammary gland experiencing neoplasia in pregnant mice (Mus musculus). We analyzed 20 pregnant mices specimens randomly divided into 5 groups. All groups were given treatment per oral with sonde till 10 days. K+ as positive control weren’t treated zearalenone and mycotoxin binders, K- as negative control were treated with zearalenone 0,1 mg/mice/day, P1 were treated with zearalenone 0,1 mg/mice/day and mycotoxin binders 0,5 mg/mice/day, P2 were treated with zearalenone 0,1 mg/mice/day and mycotoxin binders 1 mg/mice/day, P3 were treated with zearalenone 0,1 mg/mice/day and mycotoxin binders 2 mg/mice/day. The data was compared by ANOVA and to compare the mean differences among treatments tested by Duncan’s multiple range test. The result showed that the amount of grade in neoplasia had a significant difference (p<0,05) between K+, P2, P3 with P1 and K-. The conclusion in this study, mycotoxin binders 1 mg/mice/days is minimumdose to eliminate zearalenone effect.

Keyword :

Mycotoxin binders, Zearalenone, Neoplasia, Mammary gland, Pregnant mice,


References :

Bailey, R.H., L.F. Kubena, RB. Harvey, S.A. Buckley, and G.E., Rottinghous,(1998) Efficacy of various inorganic sorbents to reduce the toxicity of aflatoxin and T-2 toxin in broiler chickens . : Poult. Sci. 77:.1623-1630

Frizzell, C., D. Ndossi, S. Verhaegen, E. Dahl, G. Eriksen, M. Srrlie, E. Ropstad, M. Muller, CT. El,(2011) Endocrine disrupting effects of zearalenone, alpha- and beta-zearalenol at the level of nuclear receptor binding and steroidogenesis. . : Toxicol Lett 206: 210-217

Malekinejad, H., R.F. Mass-Bakker and J. Fink-Gremmels,(2005) Bioactivation of zearalenone by porcine hepatic biotransformation . : In Vet Research, 36 (5-6): 799-810





Archive Article

Cover Media Content

Volume : 7 / No. : 1 / Pub. : 2014-02
  1. Grant Of Ethanol Extract Of Seeds Papaya (carica Papaya) In Female Rats (rattus Novergicus) Antifertilitas Material, As An Alternative To Number And Quality Of Egg Cells
  2. Effect Of Infusum Salam Leaves (eugenia Polyantha) On Blood Glucose Level On The Rat (rattus Norwegicus) In Alloxan Induced
  3. Potential Of Phytase Ezymes From Rumen Bacteria On Sem Analysis Structural Changes Of Rice Bran As Broiler Feed
  4. The Comparison Of Morphology Between Bovine Oocyte Vitrification Before And After In Vitro Maturation
  5. The Effect Of Exposing Pregnant Rat (rattus Novergicus) To Particulate Matter On Congenital Disorder And Resorption Of Embryos
  6. Ha Gene Phyloanalysis Of Influenza H1n1 2009 Virus In Surabaya
  7. Effect Of Seminal Plasm Of Cow On Goat’s Spermatozoa Plasma Membran In Milk Diluter On Semen Freezhing
  8. Histopathological View Pyramid Cell On Cerebrum Of White Rat (rattus Norvegicus) Were Exposed With Methylmercury Which Administrated With Cdp-choline As Neuroprotective Agent
  9. Giving Epigallocathechin Gallate (egcg) Toward The Expression Of Estrogen Receptor At Female White Mouse (rattus Norvegicus)
  10. Human Resource Management Goad Farm Of The Cross Breed Etawa Goat Independent Farm, Farmer Groups And Businesses In The Town Of Turi Sleman Regency
  11. The Pattern Of Antimicrobial Susceptibility Of Salmonella Sp Isolated From Beef
  12. Potential Mycotoxin Binders On Histopathology Of The Mammary Gland Experiencing Neoplasia In Pregnant Mice (mus Musculus) With Exposed Zearalenone
  13. Potential Of Mycotoxin Binders On Weight And Length Of Fetus Pregnant Mice (mus Musculus) With Zearalenone Exposure
  14. Prevalence Of Worm Disease In Cattle Gastrointestinal Peranakan Ongole (po) And Simental Cattle In The Subdistrict Laren, District Lamongan
  15. The Giving Of Anti- Toxoplasma Gondii Membran Immunoglobulin Y Before Infection Reduce Apoptotic Index Liver Mice

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