UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 7 / No. 3 / Published : 2014-01

Order : 4, and page :224 - 231

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Original Article :

Potential of vitamin e on spermatogenic cell number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)

Author :

  1. Waode Karmila Wati*1
  2. Wurlina*2
  3. Sarmanu*3
  1. Mahasiswa Fakultas Kedokteran Hewan
  2. Dosen Fakultas Kedokteran Hewan
  3. Dosen Fakultas Kedokteran Hewan

Abstract :

The purpose of this study was to investigate the effects of vitamin E on spermatogenic cell number in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Five experimental groups of a combination of TCDD and vitamin E were designed as follows: 0 ng/kg/d and 0 mg/kg/d (control negative group P0), 100 ng/kg/d and 0 mg/kg/d (control positive group, P1), 100 ng/kg/d and 11 mg/kg/d (Group P2), 100 ng/kg/d and 20 mg/kg/d (Group P3), and 100 ng/kg/d and 37 mg/kg/d (Group P4) respectively. Vitamin E and TCDD were given by oral gavage for 5 weeks. The results demonstrated that TCDD decreased spermatogenic cell number. vitamin E at 37 mg/kg antagonized the decline of spermatogenic cell number.The results indicate that vitamin E antagonizes the reproductive endocrine toxicity and alleviates the changes in spermatogenesis caused by TCDD.

Keyword :

Vitamin E, , Spermatogenic cell, TCDD,


References :

Alsharif, N.Z. and E.A. Hassoun,(2004) Protective effects of vitamin A and vitamin E succinate against 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)- induced body wasting, hepatomegaly, thymic atrophy, production of reactive oxygen species and DNA damage in C57BL/6J mice . : Basic Clin Pharmacol Toxicol 95(3) : 131-8

Chandra, A.K., A. Chatterjee, R. Ghosh and M. Sarkar,(2010) Vitamin E-supplementation protect chromium (VI)-induced spermatogenic and steroidogenic disorders in testicular tissues of rats . : Food and Chemical Toxicology 48 : 972–979

Chang, H.J., J.S. Park, E.K. Lee, M.H. Kim, M.K. Baek, H.R. Kim, H.G. Jeong, S.Y. Choi and Y.D. Jung,(2009) Ascorbic acid suppresses the 2,3,7,8-tetrachloridibenxo-p-dioxin (TCDD)-induced CYP1A1 expression in human HepG2 cells . : Toxicology in Vitro 23: 622–626





Archive Article

Cover Media Content

Volume : 7 / No. : 3 / Pub. : 2014-11
  1. The Accuracy Of Production Equine Chorionic Gonadotropin (ecg) Frozen Dry From Local Horse For Increasing The Time Onset Of Oestrus In Madura Cattle
  2. Effect Of Infusum Kopi Leaves (coffea Robusta Lindl.) On Blood Glucose Level On The Mice In Alloxan Induced
  3. Comparison Of Sperm Quality After Separation X And Y Chromosome Between Column Albumin Method And Electric Separating Sperm (ess) Method On Ekor Gemuk Sheep
  4. Potential Of Vitamin E On Spermatogenic Cell Number In Mice Treated With 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  5. The Comparison Of Maturation Between Bovine Oocyte Vitrification Before And After In Vitro Maturation
  6. Potency Of Pediococcus Pentosaceus Protease On Meat Tenderness And Histological
  7. Effect Of Vitamin E On Decreased Of The Leydig Cell Necrosis Number In Mice Treated With 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd)
  8. The Immunomodulator Potency Of Combination Of Andrographis Paniculata And Echinacea Purpurea On Total And Differential Leucocytes Count In Mice With Heat Stress
  9. The Effect Of Various Egg Duck Concentration In Skim Milk As Semen Diluters Of Fat-tailed Sheep For Motility, Viability And Intact Plasma Membrane Spermatozoa Before Freezing
  10. Antibacterial Effect Of Mango’s Leaves (mangifera Indica) Extract Against Staphylococcus Aureus And Escherichia Coli
  11. Effectiveness Of Honey And The Juice Of Noni (morinda Citrifolia Linn) As Well As Mixtures Of The Number Of Bacteria On Chicken Carcasses
  12. The Potential Of Soursop (annona Muricata Linn.) Leaves Extract As Immunostimulantin Rabbit Pbmc
  13. Crude Protein And Crude Fiber In Rice Bran Fermented By Acidothermus Cellulolyticus Or Aspergillus Terreus Wpl 109 Or Wpl 209
  14. Level Of Contamination Of Salmonella Sp In White Prawns (litopenaeus Vannamei) Sold At Some Wet And Modern Market In Surabaya
  15. Potensi Alkaloid Achyranthes Aspera Linn Terhadap Ekspresi Protein Bax Sel Kanker Payudara Pada Mencit (mus Musculus) Yang Diinduksi Benzopyrene

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