UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 5 / No. 3 / Published : 2012-11

Order : 13, and page :227 - 231

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Original Article :

The effect of giving eugenia polyantha extract to liver histopathology on rattus norvegicus strain sprague dawley induced with dmba (dimetilbenz[a]antrasen)

Author :

  1. Hamid, I.S*1
  2. Rahmaniar, R.P*2
  3. Damayanti, Ratna*3
  4. Anwar, Husni*4
  1. Fakultas Kedokteran Hewan Universitas Airlangga
  2. PPDH Fakultas Kedokteran Hewan Universitas Airlangga
  3. Fakultas Kedokteran Hewan Universitas Airlangga
  4. Fakultas Kedokteran Hewan Universitas Airlangga

Abstract :

The purpose of this study was to evaluate the changes of liver histopathologi  after 20 mg/kg BW DMBA (Dimetilbenz[a]antrasen) induced and Eugenia polyantha extract on Sprague dawley rats liver cell.The research has been done on February, 20th 2011- December, 28th 2011 at Faculty of Veterinary Medicine,Airlangga University. 20 female rats (Rattus norvegicus strain Sprague dawley) aged 40 days with BW 60-70g were used. The rats Devided into five groups; rats in the first group was only given with DMBA and corn oil; second group was given with CMC-Na and corn oil; The third group was given with Eugenia polyantha extract  250 mg/kg Bw dose  and DMBA; The fourth and fifth group were given the same treatment as the third group, only using higher dose of Eugenia polyantha was 500 and 750 mg/kg BW. The data werecompared using Kruskal -Wallis and Mann-Withney test. Statistical comparisons were performed using SPSS18.0 for windows. This research showed that Eugenia polyantha extract with DMBA induction could inhibit necrosis of cells at dose 500 mg/kg BW but Eugenia polyantha all of dose could not inhibit portal inflamation. 

Keyword :

DMBA induction, Liver histopathology, Eugenia polyantha extract,


References :

Kleiner D.E.,(2003) Design and vasodilatasion of histologic scoring system for nonalcoholic fatty liver disease. . : Hepatology 2005; 41: 1313-21

Kolaez, G.S., J Klusek, and A. Kolataj.,(2007) The Effect of Exogenous GSH, GSSG and GST-E on Glutathion concentration and Activity of Selected Glutatione Enzimes in Liver, Kidney and Muscle of Mice. . : Journal of Animal Science. 2: 111-117





Archive Article

Cover Media Content

Volume : 5 / No. : 3 / Pub. : 2012-11
  1. Decrease Of Spermatozoa Fertility Rate And Overview Histopathologic Seminiferous Tubules Of Mice (mus Musculus) With Malnutrition Conditions
  2. Antibacterial Susceptibility Of Bacillus Subtilis Isolated From Shrimp Pond And Fish Pond Sediment
  3. The Efectivity Of Red Rose Flower(rosa Damascena Mill) Extract As An Antiseptic Toward Chronic Stomatitis On Phyton Snake (python Reticulatus)
  4. Potential Rice Bran Fermented With Enterobacter Cloacae Wpl 111 To The Crude Fiber Disgestibility Of Broiler
  5. The Decrease Of Progesterone-b Receptor Roles In Abortion Ewe By Dexamethasone Administration
  6. Antibiotic Susceptibility Pattern Of Staphylococcus Aureus Isolated From Mastitis In Dairy Cattle At Argopuro Dairy Cooperative In Krucil Probolinggo District
  7. Therapeutic Effect Of Water Extract Leaf Kedondong (lannea Coromandelica) To Levels Of Malondialdehyde (mda) And Protease Activity In Ileum Rat (rattus Norvegicus) Inflammatory Bowel Disease (ibd) Induced By Indomethacin
  8. The Dynamic Of Maturation Promoting Factor (mpf) On Cyprinus Carpio Oocytes After Induced By Artificial Activation
  9. The Role Of D-alpha Tocopherol Therapy To Blood Glucose Levels And Levels Of Mda (malondialdehyde) In Diabetes Mellitus Type 1 Rats By Mld-stz
  10. Oestrous Decrease And Ovarian Histopathologic Description Of Female Mouse (mus Musculus) With Malnutrition Condition
  11. Closed House Method To Influence Of Body Weight, Mortality Rate And Crop Periode In Broiler Farm
  12. Insulin Like Growth Factor-i Complex Sebagai Alternatif Antioksidan Pada Media Pendewasaan Spermatozoa Kambing
  13. The Effect Of Giving Eugenia Polyantha Extract To Liver Histopathology On Rattus Norvegicus Strain Sprague Dawley Induced With Dmba (dimetilbenz[a]antrasen)

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