UNIVERSITAS AIRLANGGA



Detail Article

Veterinaria Medika

ISSN 1979-1305

Vol. 3 / No. 2 / Published : 2010-07

Order : 3, and page :93 - 98

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Original Article :

The effects of eucheuma spinosum extracts on the sod (superoxide dismutase) activities on mice (rattus novergicus) induced multiple-low dose streptozotocin

Author :

  1. Anna Safitri*1
  2. Aulanni'am*2
  1. FMIPA Universitas Brawijaya
  2. FMIPA Universitas Brawijaya

Abstract :

The capacity of Eucheuma spinosum extracts to decrease blood glucose levels on mice induced multiple-lowdose streptozotocin has been reported. The extracts of Eucheuma spinosum lowered blood glucose levels on mice ingroup III by 41.24% in week 2, and by 58.42% in week 3, after therapy. Three groups of mice, including control group(group I), diabetic group (group II), and therapy group (group III), were used. Streptozotocin was given at multiple-low dose of 20 mg/kg of body weight for 5 times in 5 consecutive days i.p. to groups II and III. In this research, the therapy effects of Eucheuma spinosum extracts for diabetes mellitus were studied from the SOD (superoxide dismutase)activities. The activities of SOD showed an increase, from 27.219 1.32 unit to 42.570 1.19 unit. The recovery of pancreatic â-cells from therapeutic mice has been shown from the histology of the tissue. Therefore, Eucheumaspinosum extracts potentially could be used as an alternative for diabetes mellitus treatment.

Keyword :

Eucheuma spinosum, free radicals, mice, multiple-low dose streptozotocin, .,


References :

Li, B., F. Lu., X. Wei., and R. Zhao,(2008) Fucoidan : S t r u c t u r e a n d B i o a c t i v i t y United States : J o u r n a l molecules

Kusharto, M. C.,(2006) Serat Makanan dan Peranannya Bagi Kesehatan Jakarta : Jurnal Gizi dan Pangan

Hotta, M., Y. Eiji., and M. Jun-ichi.,(2000) Oxidative Stress and Pankreatic â-cell Destruction in Insulin Dependent Diabetes Mellitus New York : Marcel Dekker. Inc.





Archive Article

Cover Media Content

Volume : 3 / No. : 2 / Pub. : 2010-07
  1. The Effect Of Caspase 3 (caspase Excecutor) On Apoptotic Induction Endometrial Cancer Cel By Alkaloid Achyranthes Aspera Linn In Vitro
  2. Detection Of Inflamentation On Duck Moulting Therapy By Anti-prolactine Injection
  3. The Effects Of Eucheuma Spinosum Extracts On The Sod (superoxide Dismutase) Activities On Mice (rattus Novergicus) Induced Multiple-low Dose Streptozotocin
  4. Ethanol Extract Of Brown Secured (sargassum Duplicatum Bory): Phytopharmaco Exploration For Lung Cancer Therapy
  5. Using Logistic And Gompertz Model To Estimate The Body Weight Growth Of Lohmann Broiler Chicken
  6. Case Study : Suspect Feline Infectious Peritonitis (fip) Of Cat In Surabaya
  7. The Usefull Of Rice Straw, Ammoniation Rice Straw And Soybean Straw As Single Fed On Microbial Protein Synthesis Of Ongole Grade Cattle
  8. Kajian Lintas Seksional Selang Beranak (calving Interval) Pada Tingkat Ternak Dan Peternak Pada Sapi Perah Di Jawa Timur
  9. Supplementation Of Insulin Like Growth Factor – I Complex Protein Of Goat Seminal Plasma To Quality Of Acrosome Cap Of Sperm After Centrifugation
  10. Concentration Of Pregnancy Associated Substances (pas) Of Ettawa Crossbreed Goats On Several Stage Of Pregnancy
  11. Motility And Viability Spermatozoa Muscovy Duck (cairina Moschata) On The Various Concentration Of Egg Yolk Fructose And Skim Milk Diluter
  12. The Use Of Indigenous Bacteria Isolated From Digestive Tract Of White Shrimp, Litopenaeus Vannamei As Microbe Pathogen Inhibitor
  13. Isolation And Identification Of Coagulase-positive Staphylococcus From Injury On Dog Skin In Surabaya
  14. Influence Of Melatonin To Histopathology Pancreas In Rat ( Rattus Norvegicus ) Experimentally Diabetes Mellitus Type I

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