UNIVERSITAS AIRLANGGA



Detail Article

BIOSAINS

ISSN 1412-1433

Vol. 13 / No. 2 / Published : 2011-05

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Original Article :

Antimalarial activity and mechanism of action of flavonoid compounds isolated from artocarpus champeden spreng stembark

Author :

  1. A ty Widyawaruyanti*1
  2. Noer Cholis Zaini*2
  3. Syafruddin*3
  1. Fakultas Farmasi Universitas Airlangga
  2. Fakultas Kedokteran Universitas Hasanuddin
  3. Fakultas Kedokteran Universitas Hasanuddin

Abstract :

This study was aimed to monitor Flavonoid Compound activity and mechanism as antimalaria that isolated from A. Champeden. Two new prenylated flavones, 5,7,2′,5′-tetrahydroxy-4′-methoxi-3-prenylflavone and 5,7,2′,4′-tetrahydroxy-8-prenylfuranodihydrobenzoxanthone, named after artocarpones A and B respectively, have been isolated from the stembark of Artocarpus champeden, together with six known isoprenylated flavonoids: artonin A, cycloheterophyllin, heterophyllin, artoindonesianin R, heteroflavanone C, artoindonesianin A-2, and one flavanone artoindonesianin E. Their structures were determined on the basis of spectroscopic analysis. The isolated compounds were all tested for their antimalarial activity against the growth of Plasmodium falciparum 3D7 in vitro and the results indicated that all but one compound, artoindonesianin E (IC50 = 75.76 μM), inhibited the parasite growth significantly. The highest antimalarial activity was shown by heteroflavanone C (IC50 = 0.001 μM). An attempt to determine its mechanism of action by using sorbitol-induced hemolysis inhibitory assay revealed that artoindonesianin R, artocarpone A and artoindonesianin A-2 showed hemolysis inhibition over 60% and, therefore, identified as inhibitor of the NPP of the infected erythrocyte. The results indicated that flavonoid compounds from this A. champeden exhibited potent antimalarial activity through either inhibition of the parasite inducing new permeation pathway or other yet unidentified mechanism. Therefore, the compounds are potential to be developed as new antimalarial drugs, through phytopharmaceutical product of its stembark or synthesized products of the compounds.

Keyword :

Artocarpus champeden stembark, , Plasmodium falciparum, , isoprenylated flavonoids, , antimalarial activity, , sorbitol-induced hemolysis assay,


References :

Achmad SA,,(2004) Empat Puluh Tahun Dalam Kimia Organik Bahan Alam Tumbuh-Tumbuhan Tropika Indonesia: Rekoleksi Dan Prospek Bull Soc Nat Prod Chem : Bull Soc Nat Prod Chem

A griana RH,(2003) Uji aktivitas antimalaria fraksi kloroform kulit batang cempedak (Artocarpus champeden) terhadap Plasmodium berghei in-vivo Surabaya : Fakultas Farmasi Unair

Aida M, Shinomiya K, Hano Y, Nomura T,(1993) Artonin J, K, and L, three new isoprenylated flavones from the root bark of Artocarpus heterophyllus Lamk. Heterocycles : Heterocycles

Boonlaksiri C, Oonanant W, Kongsaeree P, Kittakoop P, Tanticharoen M, Thebtaranonth Y,(2000) An antimalarial stilbene from Artocarpus integer. J Phytochem. : J Phytochem.

DepKes,(2004) Penggunaan Artimisinin untuk Atasi Malaria di daerah yang resisten Klorokuin. Jakarta : Lembaga Ilmu Pengetahuan Indonesia





Archive Article

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Volume : 13 / No. : 2 / Pub. : 2011-05
  1. Antimalarial Activity And Mechanism Of Action Of Flavonoid Compounds Isolated From Artocarpus Champeden Spreng Stembark
  2. Studi On The Espression Of Tgf-b1 Mmp-9, Collagen Type-i, Collagen Tipe-iv, Glomerulosclerosis, Interstisial Fibrosis, And Albuminuria In Hephrotoxic Docorubin And Nephroprotective Pentoxifyllin Events On Male Swiss-strain Mice
  3. Characterization Of Physical Properties From Human Enamel Induced By Nd:yag Pulsed Laser Based On Laser Speckle Imaging System
  4. Protein Expression Of Cox-2 In High And Low Response In Nasopharynx Carcinoma After Radiotherapy
  5. Gene Polymorphism Of Mthfr C677t And Ts 5’-utr 3r/3r, On Childhood Acute Lymphoblastic Leukemia Resistance To Methotrexate
  6. Effective Growth Medium, Light Intensity And Length Of Radiation For Culturing Isolated Microcystis From Sutami Reservoir In Laboratory
  7. Nutrition And Iron Status In Children With Tb Parents, Their Role On Infection And Disease

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